Self-Assembly and Lyomesophases Formed by Long-Chain Alkoxymethyl-Nucleobase Derivatives

Self-Assembly and Lyomesophases Formed by Long-Chain Alkoxymethyl-Nucleobase Derivatives

Amphiphilic complementary nucleobase derivatives, containing n-octadecyl-oxymethyl substituents at the N 1 position of pyrimidine and N 9 of purine, dissolved in chloroform form non-specific lyotropic mesophases, which were analyzed by optical polarizing microscopy. Molecular modeling studies visual...

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Veröffentlicht in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2000-07, Vol.19 (7), p.1185-1191
Hauptverfasser: Meister, W. V., Lindau, S., Bohley, C., Gromann, U., Madre, M., Kovalenko, L., Bischoff, G., Zhuk, R., Hoffmann, S.
Format: Artikel
Sprache:eng
Schlagworte:
Chloroform - chemistry
DNA - chemical synthesis
DNA - chemistry
Hydrogen Bonding
Microscopy, Polarization
Models, Molecular
Nucleic Acid Conformation
Nucleosides - chemical synthesis
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Zusammenfassung:Amphiphilic complementary nucleobase derivatives, containing n-octadecyl-oxymethyl substituents at the N 1 position of pyrimidine and N 9 of purine, dissolved in chloroform form non-specific lyotropic mesophases, which were analyzed by optical polarizing microscopy. Molecular modeling studies visualize hypothetical horizontal and vertical nucleobase hydrogen-bonding and stacking arrangements, as well as aliphatic long-chain interstrand interaction.
ISSN:1525-7770
1532-2335
DOI:10.1080/15257770008035039