Amiodarone-induced bone marrow granulomas
Summary Amiodarone hydrochloride, a class III antiarrhythmic agent used to treat supraventricular and ventricular cardiac dysrhythmias. In this report we describe two patients receiving amiodarone for atrial fibrillation who underwent bone marrow biopsies to investigate paraproteinaemia (case 1) or...
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| Veröffentlicht in: | Clinical and laboratory haematology 2000-06, Vol.22 (3), p.167-170 |
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| container_title | Clinical and laboratory haematology |
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| creator | Boutros, N.Y.Z. Dilly, S. Bevan, D.H. |
| description | Summary
Amiodarone hydrochloride, a class III antiarrhythmic agent used to treat supraventricular and ventricular cardiac dysrhythmias.
In this report we describe two patients receiving amiodarone for atrial fibrillation who underwent bone marrow biopsies to investigate paraproteinaemia (case 1) or severe thrombocytopenia (case 2). Multiple bone marrow granulomas were found in both patients, without evidence of any other cause. In both patients the granulomas disappeared after amiodarone withdrawal, suggesting a direct association. |
| doi_str_mv | 10.1046/j.1365-2257.2000.00266.x |
| format | Article |
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Amiodarone hydrochloride, a class III antiarrhythmic agent used to treat supraventricular and ventricular cardiac dysrhythmias.
In this report we describe two patients receiving amiodarone for atrial fibrillation who underwent bone marrow biopsies to investigate paraproteinaemia (case 1) or severe thrombocytopenia (case 2). Multiple bone marrow granulomas were found in both patients, without evidence of any other cause. In both patients the granulomas disappeared after amiodarone withdrawal, suggesting a direct association.</description><identifier>ISSN: 0141-9854</identifier><identifier>EISSN: 1365-2257</identifier><identifier>DOI: 10.1046/j.1365-2257.2000.00266.x</identifier><identifier>PMID: 10931167</identifier><identifier>CODEN: CLHAD3</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Aged ; Amiodarone ; Amiodarone - adverse effects ; Anti-Arrhythmia Agents - adverse effects ; Atrial Fibrillation - complications ; Atrial Fibrillation - drug therapy ; Biological and medical sciences ; Biopsy ; bone marrow ; Bone Marrow Diseases - chemically induced ; Drug toxicity and drugs side effects treatment ; Female ; Granuloma - chemically induced ; Humans ; Male ; Medical sciences ; non-caseating granuloma ; Pharmacology. Drug treatments ; thrombocytopenia ; Toxicity: blood</subject><ispartof>Clinical and laboratory haematology, 2000-06, Vol.22 (3), p.167-170</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3836-f75d8ad1c356831f5c452bbc721a358b889eab67738d61ec840f544b2e3d7b2b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2257.2000.00266.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2257.2000.00266.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1426474$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10931167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boutros, N.Y.Z.</creatorcontrib><creatorcontrib>Dilly, S.</creatorcontrib><creatorcontrib>Bevan, D.H.</creatorcontrib><title>Amiodarone-induced bone marrow granulomas</title><title>Clinical and laboratory haematology</title><addtitle>Clin Lab Haematol</addtitle><description>Summary
Amiodarone hydrochloride, a class III antiarrhythmic agent used to treat supraventricular and ventricular cardiac dysrhythmias.
In this report we describe two patients receiving amiodarone for atrial fibrillation who underwent bone marrow biopsies to investigate paraproteinaemia (case 1) or severe thrombocytopenia (case 2). Multiple bone marrow granulomas were found in both patients, without evidence of any other cause. In both patients the granulomas disappeared after amiodarone withdrawal, suggesting a direct association.</description><subject>Aged</subject><subject>Amiodarone</subject><subject>Amiodarone - adverse effects</subject><subject>Anti-Arrhythmia Agents - adverse effects</subject><subject>Atrial Fibrillation - complications</subject><subject>Atrial Fibrillation - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>bone marrow</subject><subject>Bone Marrow Diseases - chemically induced</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Granuloma - chemically induced</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>non-caseating granuloma</subject><subject>Pharmacology. Drug treatments</subject><subject>thrombocytopenia</subject><subject>Toxicity: blood</subject><issn>0141-9854</issn><issn>1365-2257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1PwkAURSdGI4j-BdOFGxet8z3DwgWCAoZoJBqNm8l81RRbSloJ8O-dCqKrNy9z7svNASBCMEGQ8qtZgghnMcZMJBhCmECIOU_WB6C9_zgEbYgoiruS0RY4qesZhIggIY5BC8EuQYiLNrjsFVnpdFXOfZzN3dJ6F5mwRIWuqnIVfVR6vszLQten4CjVee3PdrMDXu5un_ujePI4HPd7k9gSSXicCuakdsgSxiVBKbOUYWOswEgTJo2UXa8NF4JIx5G3ksKUUWqwJ04YbEgHnG_vLpam8E4tqix02ajfzgG42AG6tjpPQ0Ob1X8cxZwKGrDrLbbKcr_5d0Y1CtVMNaZUY0o1CtWPQrVW4_vJKLxCPt7ms_rLr_d5XX2qUEIw9fowVG_T95tpXw7UE_kGl2ByPg</recordid><startdate>200006</startdate><enddate>200006</enddate><creator>Boutros, N.Y.Z.</creator><creator>Dilly, S.</creator><creator>Bevan, D.H.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200006</creationdate><title>Amiodarone-induced bone marrow granulomas</title><author>Boutros, N.Y.Z. ; Dilly, S. ; Bevan, D.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3836-f75d8ad1c356831f5c452bbc721a358b889eab67738d61ec840f544b2e3d7b2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Amiodarone</topic><topic>Amiodarone - adverse effects</topic><topic>Anti-Arrhythmia Agents - adverse effects</topic><topic>Atrial Fibrillation - complications</topic><topic>Atrial Fibrillation - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>bone marrow</topic><topic>Bone Marrow Diseases - chemically induced</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Granuloma - chemically induced</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>non-caseating granuloma</topic><topic>Pharmacology. Drug treatments</topic><topic>thrombocytopenia</topic><topic>Toxicity: blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boutros, N.Y.Z.</creatorcontrib><creatorcontrib>Dilly, S.</creatorcontrib><creatorcontrib>Bevan, D.H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Clinical and laboratory haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boutros, N.Y.Z.</au><au>Dilly, S.</au><au>Bevan, D.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amiodarone-induced bone marrow granulomas</atitle><jtitle>Clinical and laboratory haematology</jtitle><addtitle>Clin Lab Haematol</addtitle><date>2000-06</date><risdate>2000</risdate><volume>22</volume><issue>3</issue><spage>167</spage><epage>170</epage><pages>167-170</pages><issn>0141-9854</issn><eissn>1365-2257</eissn><coden>CLHAD3</coden><abstract>Summary
Amiodarone hydrochloride, a class III antiarrhythmic agent used to treat supraventricular and ventricular cardiac dysrhythmias.
In this report we describe two patients receiving amiodarone for atrial fibrillation who underwent bone marrow biopsies to investigate paraproteinaemia (case 1) or severe thrombocytopenia (case 2). Multiple bone marrow granulomas were found in both patients, without evidence of any other cause. In both patients the granulomas disappeared after amiodarone withdrawal, suggesting a direct association.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>10931167</pmid><doi>10.1046/j.1365-2257.2000.00266.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0141-9854 |
| ispartof | Clinical and laboratory haematology, 2000-06, Vol.22 (3), p.167-170 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Aged Amiodarone Amiodarone - adverse effects Anti-Arrhythmia Agents - adverse effects Atrial Fibrillation - complications Atrial Fibrillation - drug therapy Biological and medical sciences Biopsy bone marrow Bone Marrow Diseases - chemically induced Drug toxicity and drugs side effects treatment Female Granuloma - chemically induced Humans Male Medical sciences non-caseating granuloma Pharmacology. Drug treatments thrombocytopenia Toxicity: blood |
| title | Amiodarone-induced bone marrow granulomas |
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