Amiodarone-induced bone marrow granulomas

Summary Amiodarone hydrochloride, a class III antiarrhythmic agent used to treat supraventricular and ventricular cardiac dysrhythmias. In this report we describe two patients receiving amiodarone for atrial fibrillation who underwent bone marrow biopsies to investigate paraproteinaemia (case 1) or...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical and laboratory haematology 2000-06, Vol.22 (3), p.167-170
Hauptverfasser:	Boutros, N.Y.Z., Dilly, S., Bevan, D.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amiodarone Amiodarone - adverse effects Anti-Arrhythmia Agents - adverse effects Atrial Fibrillation - complications Atrial Fibrillation - drug therapy Biological and medical sciences Biopsy bone marrow Bone Marrow Diseases - chemically induced Drug toxicity and drugs side effects treatment Female Granuloma - chemically induced Humans Male Medical sciences non-caseating granuloma Pharmacology. Drug treatments thrombocytopenia Toxicity: blood
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Summary Amiodarone hydrochloride, a class III antiarrhythmic agent used to treat supraventricular and ventricular cardiac dysrhythmias. In this report we describe two patients receiving amiodarone for atrial fibrillation who underwent bone marrow biopsies to investigate paraproteinaemia (case 1) or severe thrombocytopenia (case 2). Multiple bone marrow granulomas were found in both patients, without evidence of any other cause. In both patients the granulomas disappeared after amiodarone withdrawal, suggesting a direct association.
ISSN:	0141-9854 1365-2257
DOI:	10.1046/j.1365-2257.2000.00266.x