Synthesis of [bis(Inosine-5′)]-tetraphosphate and [bis(Inosine-5′)]-pentaphosphate Analogues Bearing the Residues of Methylenediphosphonic Acid

Synthesis of [bis(Inosine-5′)]-tetraphosphate and [bis(Inosine-5′)]-pentaphosphate Analogues Bearing the Residues of Methylenediphosphonic Acid

Various methods of synthesis of metabolically stable phosphonate analogues of bisnucleoside oligophosphates containing two residues of methylenediphosphonic acid in the oligophosphate chain are studied. Phosphonate analogues of Ip 4 I and Ip 5 I are prepared.

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Bibliographische Detailangaben
Veröffentlicht in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2000-05, Vol.19 (5-6), p.881-889
Hauptverfasser: Shipitsyn, A. V., Tarussova, N. B., Shirokova, E. A., Krayevsky, A. A.
Format: Artikel
Sprache:eng
Schlagworte:
Inosine Nucleotides - chemical synthesis
Magnetic Resonance Spectroscopy
Mass Spectrometry
Organophosphonates - chemical synthesis
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Spectrophotometry, Ultraviolet
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Beschreibung
Zusammenfassung:Various methods of synthesis of metabolically stable phosphonate analogues of bisnucleoside oligophosphates containing two residues of methylenediphosphonic acid in the oligophosphate chain are studied. Phosphonate analogues of Ip 4 I and Ip 5 I are prepared.
ISSN:1525-7770
1532-2335
DOI:10.1080/15257770008033029