Organ Culture Model for the Study of HVH-II Infections in Carcinoma of the Cervix
An experimental model is described whereby human and monkey cervical tissues may be maintained as organ cultures for 21 and 40 days, respectively. Inclusion of sodium carboxymethyl cellulose in the culture medium prolongs the survival time of tissues considerably. The sequential cytologic changes as...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1979-05, Vol.53 (5), p.559-564 |
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| container_end_page | 564 |
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| container_issue | 5 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
| container_volume | 53 |
| creator | TOBIN, S M FISH, E N WILSON, W D PAPSIN, F R |
| description | An experimental model is described whereby human and monkey cervical tissues may be maintained as organ cultures for 21 and 40 days, respectively. Inclusion of sodium carboxymethyl cellulose in the culture medium prolongs the survival time of tissues considerably. The sequential cytologic changes associated with herpesvirus hominis type II (HVH-II) infection are reported. These changes are considered in relation to the possible causal role of HVH-II infection in cervical carcinogenesis. |
| format | Article |
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Inclusion of sodium carboxymethyl cellulose in the culture medium prolongs the survival time of tissues considerably. The sequential cytologic changes associated with herpesvirus hominis type II (HVH-II) infection are reported. These changes are considered in relation to the possible causal role of HVH-II infection in cervical carcinogenesis.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>PMID: 108642</identifier><language>eng</language><publisher>United States: The American College of Obstetricians and Gynecologists</publisher><subject>Animals ; Carboxymethylcellulose Sodium ; Culture Media ; Epithelium - pathology ; Female ; Haplorhini ; Herpes Simplex - complications ; Herpes Simplex - pathology ; Humans ; Models, Biological ; Organ Culture Techniques ; Precancerous Conditions ; Uterine Cervical Neoplasms - etiology ; Uterine Cervical Neoplasms - pathology</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1979-05, Vol.53 (5), p.559-564</ispartof><rights>1979 The American College of Obstetricians and Gynecologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/108642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TOBIN, S M</creatorcontrib><creatorcontrib>FISH, E N</creatorcontrib><creatorcontrib>WILSON, W D</creatorcontrib><creatorcontrib>PAPSIN, F R</creatorcontrib><title>Organ Culture Model for the Study of HVH-II Infections in Carcinoma of the Cervix</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>An experimental model is described whereby human and monkey cervical tissues may be maintained as organ cultures for 21 and 40 days, respectively. Inclusion of sodium carboxymethyl cellulose in the culture medium prolongs the survival time of tissues considerably. The sequential cytologic changes associated with herpesvirus hominis type II (HVH-II) infection are reported. These changes are considered in relation to the possible causal role of HVH-II infection in cervical carcinogenesis.</description><subject>Animals</subject><subject>Carboxymethylcellulose Sodium</subject><subject>Culture Media</subject><subject>Epithelium - pathology</subject><subject>Female</subject><subject>Haplorhini</subject><subject>Herpes Simplex - complications</subject><subject>Herpes Simplex - pathology</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Organ Culture Techniques</subject><subject>Precancerous Conditions</subject><subject>Uterine Cervical Neoplasms - etiology</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotUNtOhDAQbYw3XP0DH_oDTVqGtvTREHVJ1myMl_hGSmkF5ZYCrvv3QvBpMnMumXNOUMBiCSQE-DhFAaWhIjKOokt0NQxflFImFFygc0ZjEYUBet77T93iZKrHyVv81BW2xq7zeCwtfhmn4og7h7fvW5KmOG2dNWPVtQOuZo32pmq7Ri-MhZ5Y_1P9XqMzp-vB3vzPDXp7uH9NtmS3f0yTux3pQ045EabQKpQgQOZGSzAyogJiYxSPnHPMWMq4AHCx4DosbC4KoUEa5vLYMc5hg25X337KG1tkva8a7Y_ZmmyGoxU-dPVo_fBdTwfrs9LqeiyzuQgq5j8IU1JRPm9kOXH4A31fWWY</recordid><startdate>197905</startdate><enddate>197905</enddate><creator>TOBIN, S M</creator><creator>FISH, E N</creator><creator>WILSON, W D</creator><creator>PAPSIN, F R</creator><general>The American College of Obstetricians and Gynecologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>197905</creationdate><title>Organ Culture Model for the Study of HVH-II Infections in Carcinoma of the Cervix</title><author>TOBIN, S M ; FISH, E N ; WILSON, W D ; PAPSIN, F R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2505-6cda9273637bca73c740638cc954fff1ce015633f865a2deb6d6a37c1fb8f1553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Carboxymethylcellulose Sodium</topic><topic>Culture Media</topic><topic>Epithelium - pathology</topic><topic>Female</topic><topic>Haplorhini</topic><topic>Herpes Simplex - complications</topic><topic>Herpes Simplex - pathology</topic><topic>Humans</topic><topic>Models, Biological</topic><topic>Organ Culture Techniques</topic><topic>Precancerous Conditions</topic><topic>Uterine Cervical Neoplasms - etiology</topic><topic>Uterine Cervical Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TOBIN, S M</creatorcontrib><creatorcontrib>FISH, E N</creatorcontrib><creatorcontrib>WILSON, W D</creatorcontrib><creatorcontrib>PAPSIN, F R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TOBIN, S M</au><au>FISH, E N</au><au>WILSON, W D</au><au>PAPSIN, F R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Organ Culture Model for the Study of HVH-II Infections in Carcinoma of the Cervix</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1979-05</date><risdate>1979</risdate><volume>53</volume><issue>5</issue><spage>559</spage><epage>564</epage><pages>559-564</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><abstract>An experimental model is described whereby human and monkey cervical tissues may be maintained as organ cultures for 21 and 40 days, respectively. Inclusion of sodium carboxymethyl cellulose in the culture medium prolongs the survival time of tissues considerably. The sequential cytologic changes associated with herpesvirus hominis type II (HVH-II) infection are reported. These changes are considered in relation to the possible causal role of HVH-II infection in cervical carcinogenesis.</abstract><cop>United States</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>108642</pmid><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0029-7844 |
| ispartof | Obstetrics and gynecology (New York. 1953), 1979-05, Vol.53 (5), p.559-564 |
| issn | 0029-7844 1873-233X |
| language | eng |
| recordid | cdi_pubmed_primary_108642 |
| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Animals Carboxymethylcellulose Sodium Culture Media Epithelium - pathology Female Haplorhini Herpes Simplex - complications Herpes Simplex - pathology Humans Models, Biological Organ Culture Techniques Precancerous Conditions Uterine Cervical Neoplasms - etiology Uterine Cervical Neoplasms - pathology |
| title | Organ Culture Model for the Study of HVH-II Infections in Carcinoma of the Cervix |
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