Organ Culture Model for the Study of HVH-II Infections in Carcinoma of the Cervix

Organ Culture Model for the Study of HVH-II Infections in Carcinoma of the Cervix

An experimental model is described whereby human and monkey cervical tissues may be maintained as organ cultures for 21 and 40 days, respectively. Inclusion of sodium carboxymethyl cellulose in the culture medium prolongs the survival time of tissues considerably. The sequential cytologic changes as...

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Veröffentlicht in:Obstetrics and gynecology (New York. 1953) 1979-05, Vol.53 (5), p.559-564
Hauptverfasser: TOBIN, S M, FISH, E N, WILSON, W D, PAPSIN, F R
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Carboxymethylcellulose Sodium
Culture Media
Epithelium - pathology
Female
Haplorhini
Herpes Simplex - complications
Herpes Simplex - pathology
Humans
Models, Biological
Organ Culture Techniques
Precancerous Conditions
Uterine Cervical Neoplasms - etiology
Uterine Cervical Neoplasms - pathology
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Zusammenfassung:An experimental model is described whereby human and monkey cervical tissues may be maintained as organ cultures for 21 and 40 days, respectively. Inclusion of sodium carboxymethyl cellulose in the culture medium prolongs the survival time of tissues considerably. The sequential cytologic changes associated with herpesvirus hominis type II (HVH-II) infection are reported. These changes are considered in relation to the possible causal role of HVH-II infection in cervical carcinogenesis.
ISSN:0029-7844
1873-233X