Antimitotic diterpenes from Erythropodium caribaeorum test pharmacophore models for microtubule stabilization
[structure: see text] Six new antimitotic diterpenes, 2-7, have been isolated from the Caribbean octocoral Erythropodium caribaeorum. Structural variations encountered in this group of natural products test recently proposed pharmacophore models for microtubule stabilizing compounds.
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| Veröffentlicht in: | Organic letters 2000-02, Vol.2 (3), p.257 |
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| container_issue | 3 |
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| container_title | Organic letters |
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| creator | Cinel, B Roberge, M Behrisch, H van Ofwegen, L Castro, C B Andersen, R J |
| description | [structure: see text] Six new antimitotic diterpenes, 2-7, have been isolated from the Caribbean octocoral Erythropodium caribaeorum. Structural variations encountered in this group of natural products test recently proposed pharmacophore models for microtubule stabilizing compounds. |
| doi_str_mv | 10.1021/ol9912027 |
| format | Article |
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| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2000-02, Vol.2 (3), p.257 |
| issn | 1523-7060 |
| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Cell Cycle - drug effects Cell Death - drug effects Cnidaria - chemistry Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Inhibitory Concentration 50 Microtubules - chemistry Models, Molecular Structure-Activity Relationship |
| title | Antimitotic diterpenes from Erythropodium caribaeorum test pharmacophore models for microtubule stabilization |
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