Antimitotic diterpenes from Erythropodium caribaeorum test pharmacophore models for microtubule stabilization

[structure: see text] Six new antimitotic diterpenes, 2-7, have been isolated from the Caribbean octocoral Erythropodium caribaeorum. Structural variations encountered in this group of natural products test recently proposed pharmacophore models for microtubule stabilizing compounds.

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Veröffentlicht in:	Organic letters 2000-02, Vol.2 (3), p.257
Hauptverfasser:	Cinel, B, Roberge, M, Behrisch, H, van Ofwegen, L, Castro, C B, Andersen, R J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Cell Cycle - drug effects Cell Death - drug effects Cnidaria - chemistry Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Inhibitory Concentration 50 Microtubules - chemistry Models, Molecular Structure-Activity Relationship
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Zusammenfassung:	[structure: see text] Six new antimitotic diterpenes, 2-7, have been isolated from the Caribbean octocoral Erythropodium caribaeorum. Structural variations encountered in this group of natural products test recently proposed pharmacophore models for microtubule stabilizing compounds.
ISSN:	1523-7060
DOI:	10.1021/ol9912027