The Many Faces of DNA Polymerases: Strategies for Mutagenesis and for Mutational Avoidance

A current working hypothesis is that when highly processive semiconservative DNA replication is arrested at lesions in DNA, the replicative machinery is displaced from the replication fork and replaced by DNA polymerases.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-05, Vol.97 (11), p.5681-5683
Hauptverfasser:	Friedberg, Errol C., Feaver, William J., Gerlach, Valerie L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Bacterial Proteins - physiology Commentaries Deoxyribonucleic acid Dimers DNA DNA Damage DNA repair DNA Replication DNA-Directed DNA Polymerase - classification DNA-Directed DNA Polymerase - physiology Enzymes Escherichia coli - enzymology Escherichia coli - genetics Eukaryotic Cells - enzymology Fungal Proteins - genetics Fungal Proteins - physiology Genes Genetic mutation Genetics Humans Lesions Mutagenesis Mutation Nucleotides Peptide Fragments - genetics Peptide Fragments - metabolism Prokaryotic Cells - enzymology Protein Structure, Tertiary Proteins - genetics Proteins - physiology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Terminology as Topic Yeasts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A current working hypothesis is that when highly processive semiconservative DNA replication is arrested at lesions in DNA, the replicative machinery is displaced from the replication fork and replaced by DNA polymerases.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.120152397