Synthesis of 4'-substituted nucleosides and their biological evaluation
4'-C-Ethynyl-beta-D-arabino- and 4'-C-ethynyl-beta-D-2'-deoxy-ribo-pentofuranosyl pyrimidines were synthesized. Most of these 4'-ethynyl nucleosides showed interesting biological activities.
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| Veröffentlicht in: | Nucleic acids symposium series (1979) 1999 (42), p.127 |
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| container_issue | 42 |
| container_start_page | 127 |
| container_title | Nucleic acids symposium series (1979) |
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| creator | Kohgo, S Kodama, E Shigeta, S Saneyoshi, M Machida, H Ohrui, H |
| description | 4'-C-Ethynyl-beta-D-arabino- and 4'-C-ethynyl-beta-D-2'-deoxy-ribo-pentofuranosyl pyrimidines were synthesized. Most of these 4'-ethynyl nucleosides showed interesting biological activities. |
| format | Article |
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| identifier | ISSN: 0261-3166 |
| ispartof | Nucleic acids symposium series (1979), 1999 (42), p.127 |
| issn | 0261-3166 |
| language | eng |
| recordid | cdi_pubmed_primary_10780412 |
| source | Oxford Journals Open Access Collection; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Anti-HIV Agents - chemical synthesis Anti-HIV Agents - pharmacology Antimetabolites, Antineoplastic - chemical synthesis Antimetabolites, Antineoplastic - toxicity Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Cell Division - drug effects Cell Line Drug Design Herpesvirus 1, Human - drug effects Herpesvirus 2, Human - drug effects HIV - drug effects Humans Indicators and Reagents KB Cells Leukemia P388 Mice Nucleosides - chemical synthesis Nucleosides - pharmacology |
| title | Synthesis of 4'-substituted nucleosides and their biological evaluation |
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