Synthesis of 4'-substituted nucleosides and their biological evaluation

4'-C-Ethynyl-beta-D-arabino- and 4'-C-ethynyl-beta-D-2'-deoxy-ribo-pentofuranosyl pyrimidines were synthesized. Most of these 4'-ethynyl nucleosides showed interesting biological activities.

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Bibliographische Detailangaben
Veröffentlicht in:	Nucleic acids symposium series (1979) 1999 (42), p.127
Hauptverfasser:	Kohgo, S, Kodama, E, Shigeta, S, Saneyoshi, M, Machida, H, Ohrui, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-HIV Agents - chemical synthesis Anti-HIV Agents - pharmacology Antimetabolites, Antineoplastic - chemical synthesis Antimetabolites, Antineoplastic - toxicity Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Cell Division - drug effects Cell Line Drug Design Herpesvirus 1, Human - drug effects Herpesvirus 2, Human - drug effects HIV - drug effects Humans Indicators and Reagents KB Cells Leukemia P388 Mice Nucleosides - chemical synthesis Nucleosides - pharmacology
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Beschreibung
Zusammenfassung:	4'-C-Ethynyl-beta-D-arabino- and 4'-C-ethynyl-beta-D-2'-deoxy-ribo-pentofuranosyl pyrimidines were synthesized. Most of these 4'-ethynyl nucleosides showed interesting biological activities.
ISSN:	0261-3166