Efficacy of Topical Acyclovir Monophosphate, Acyclovir, or Penciclovir in Orofacial HSV-1 Infections of Mice and Genital HSV-2 Infections of Guinea Pigs
The purpose of these studies was to compare the efficacy of acyclovir monophosphate (ACVMP), acyclovir (ACV), or penciclovir (PCV) against HSV-1 in an orofacial infection of mice and against ACV sensitive and resistant genital HSV-2 infections of guinea pigs. Treatment was initiated 24, 48, or 72 ho...
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| Veröffentlicht in: | Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2000-01, Vol.19 (1-2), p.501-513 |
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| container_title | Nucleosides, nucleotides & nucleic acids |
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| creator | Kern, Earl R. Palmer, Joyce Szczech, George Painter, George Hostetler, Karl Y. |
| description | The purpose of these studies was to compare the efficacy of acyclovir monophosphate (ACVMP), acyclovir (ACV), or penciclovir (PCV) against HSV-1 in an orofacial infection of mice and against ACV sensitive and resistant genital HSV-2 infections of guinea pigs. Treatment was initiated 24, 48, or 72 hours post inoculation with 5% ACVMP, 5% ACV (Zovirax) or 1% PCV (Denavir). In all experiments, similar efficacy was obtained for ACVMP and ACV, whereas PCV was considerably less effective. |
| doi_str_mv | 10.1080/15257770008033024 |
| format | Article |
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Treatment was initiated 24, 48, or 72 hours post inoculation with 5% ACVMP, 5% ACV (Zovirax) or 1% PCV (Denavir). 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| identifier | ISSN: 1525-7770 |
| ispartof | Nucleosides, nucleotides & nucleic acids, 2000-01, Vol.19 (1-2), p.501-513 |
| issn | 1525-7770 1532-2335 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Journals Complete |
| subjects | Acyclovir - administration & dosage Acyclovir - analogs & derivatives Acyclovir - therapeutic use Administration, Topical Animals Antiviral Agents - administration & dosage Antiviral Agents - therapeutic use Female Guinea Pigs Herpes Genitalis - drug therapy Herpes Genitalis - pathology Herpes Labialis - drug therapy Herpes Labialis - pathology Herpesvirus 1, Human - drug effects Herpesvirus 2, Human - drug effects Mice Mice, Hairless |
| title | Efficacy of Topical Acyclovir Monophosphate, Acyclovir, or Penciclovir in Orofacial HSV-1 Infections of Mice and Genital HSV-2 Infections of Guinea Pigs |
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