Efficacy of Topical Acyclovir Monophosphate, Acyclovir, or Penciclovir in Orofacial HSV-1 Infections of Mice and Genital HSV-2 Infections of Guinea Pigs

The purpose of these studies was to compare the efficacy of acyclovir monophosphate (ACVMP), acyclovir (ACV), or penciclovir (PCV) against HSV-1 in an orofacial infection of mice and against ACV sensitive and resistant genital HSV-2 infections of guinea pigs. Treatment was initiated 24, 48, or 72 ho...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2000-01, Vol.19 (1-2), p.501-513
Hauptverfasser:	Kern, Earl R., Palmer, Joyce, Szczech, George, Painter, George, Hostetler, Karl Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir - administration & dosage Acyclovir - analogs & derivatives Acyclovir - therapeutic use Administration, Topical Animals Antiviral Agents - administration & dosage Antiviral Agents - therapeutic use Female Guinea Pigs Herpes Genitalis - drug therapy Herpes Genitalis - pathology Herpes Labialis - drug therapy Herpes Labialis - pathology Herpesvirus 1, Human - drug effects Herpesvirus 2, Human - drug effects Mice Mice, Hairless
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The purpose of these studies was to compare the efficacy of acyclovir monophosphate (ACVMP), acyclovir (ACV), or penciclovir (PCV) against HSV-1 in an orofacial infection of mice and against ACV sensitive and resistant genital HSV-2 infections of guinea pigs. Treatment was initiated 24, 48, or 72 hours post inoculation with 5% ACVMP, 5% ACV (Zovirax) or 1% PCV (Denavir). In all experiments, similar efficacy was obtained for ACVMP and ACV, whereas PCV was considerably less effective.
ISSN:	1525-7770 1532-2335
DOI:	10.1080/15257770008033024