Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms : Frequent expression in renal cell carcinoma and endometrial stromal sarcoma
We tested 505 cases of nonhematopoietic neoplasms by immunohistochemistry using a newly characterized monoclonal antibody (clone 56C6) against the CD10 antigen. CD10 was expressed widely in neoplasms of the genitourinary tract, including 41 (89%) of 46 cases of renal cell carcinoma, 13 (54%) of 24 c...
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Veröffentlicht in: | American journal of clinical pathology 2000-03, Vol.113 (3), p.374-382 |
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description | We tested 505 cases of nonhematopoietic neoplasms by immunohistochemistry using a newly characterized monoclonal antibody (clone 56C6) against the CD10 antigen. CD10 was expressed widely in neoplasms of the genitourinary tract, including 41 (89%) of 46 cases of renal cell carcinoma, 13 (54%) of 24 cases of transitional cell carcinoma, and 11 (61%) of 18 cases of prostatic adenocarcinoma. In addition, 5 (100%) of 5 endometrial stromal sarcomas, 3 (60%) of 5 rhabdomyosarcomas, 7 (50%) of 14 pancreatic adenocarcinomas, 5 (45%) of 11 cases of schwannoma, and 12 (40%) of 30 cases of malignant melanoma also were positive for CD10. Similar to normal tissue, CD10 positivity was restricted to the apical surface of malignant glandular cells of well-differentiated colonic, pancreatic, and prostatic adenocarcinoma, whereas in poorly differentiated adenocarcinoma and other tumors, such as melanoma, transitional cell carcinoma, renal cell carcinoma, and endometrial stromal sarcoma, the CD10 positivity showed diffuse cytoplasmic or membranous/Golgi patterns. The monoclonal antibody clone 56C6 is a reliable marker for CD10 in paraffin immunohistochemistry after heat-induced epitope retrieval. CD10 expression in renal cell carcinoma and endometrial stromal sarcoma may be a useful marker in the differential diagnoses of these tumors because both tumors otherwise lack specific markers. |
doi_str_mv | 10.1309/8vav-j2fu-8cu9-ek18 |
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A</creator><creatorcontrib>PEIGUO CHU ; ARBER, D. A</creatorcontrib><description>We tested 505 cases of nonhematopoietic neoplasms by immunohistochemistry using a newly characterized monoclonal antibody (clone 56C6) against the CD10 antigen. CD10 was expressed widely in neoplasms of the genitourinary tract, including 41 (89%) of 46 cases of renal cell carcinoma, 13 (54%) of 24 cases of transitional cell carcinoma, and 11 (61%) of 18 cases of prostatic adenocarcinoma. In addition, 5 (100%) of 5 endometrial stromal sarcomas, 3 (60%) of 5 rhabdomyosarcomas, 7 (50%) of 14 pancreatic adenocarcinomas, 5 (45%) of 11 cases of schwannoma, and 12 (40%) of 30 cases of malignant melanoma also were positive for CD10. Similar to normal tissue, CD10 positivity was restricted to the apical surface of malignant glandular cells of well-differentiated colonic, pancreatic, and prostatic adenocarcinoma, whereas in poorly differentiated adenocarcinoma and other tumors, such as melanoma, transitional cell carcinoma, renal cell carcinoma, and endometrial stromal sarcoma, the CD10 positivity showed diffuse cytoplasmic or membranous/Golgi patterns. The monoclonal antibody clone 56C6 is a reliable marker for CD10 in paraffin immunohistochemistry after heat-induced epitope retrieval. CD10 expression in renal cell carcinoma and endometrial stromal sarcoma may be a useful marker in the differential diagnoses of these tumors because both tumors otherwise lack specific markers.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/8vav-j2fu-8cu9-ek18</identifier><identifier>PMID: 10705818</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Antigens, Neoplasm ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Carcinoembryonic Antigen - analysis ; Carcinoma, Renal Cell - chemistry ; Carcinoma, Renal Cell - pathology ; Diagnosis, Differential ; Endometrial Neoplasms - chemistry ; Endometrial Neoplasms - pathology ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Hematologic Neoplasms - chemistry ; Hematologic Neoplasms - pathology ; Humans ; Immunoenzyme Techniques ; Kidney Neoplasms - chemistry ; Kidney Neoplasms - pathology ; Kidneys ; Male ; MART-1 Antigen ; Medical sciences ; Neoplasm Proteins - analysis ; Nephrology. 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A</creatorcontrib><title>Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms : Frequent expression in renal cell carcinoma and endometrial stromal sarcoma</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>We tested 505 cases of nonhematopoietic neoplasms by immunohistochemistry using a newly characterized monoclonal antibody (clone 56C6) against the CD10 antigen. CD10 was expressed widely in neoplasms of the genitourinary tract, including 41 (89%) of 46 cases of renal cell carcinoma, 13 (54%) of 24 cases of transitional cell carcinoma, and 11 (61%) of 18 cases of prostatic adenocarcinoma. In addition, 5 (100%) of 5 endometrial stromal sarcomas, 3 (60%) of 5 rhabdomyosarcomas, 7 (50%) of 14 pancreatic adenocarcinomas, 5 (45%) of 11 cases of schwannoma, and 12 (40%) of 30 cases of malignant melanoma also were positive for CD10. Similar to normal tissue, CD10 positivity was restricted to the apical surface of malignant glandular cells of well-differentiated colonic, pancreatic, and prostatic adenocarcinoma, whereas in poorly differentiated adenocarcinoma and other tumors, such as melanoma, transitional cell carcinoma, renal cell carcinoma, and endometrial stromal sarcoma, the CD10 positivity showed diffuse cytoplasmic or membranous/Golgi patterns. The monoclonal antibody clone 56C6 is a reliable marker for CD10 in paraffin immunohistochemistry after heat-induced epitope retrieval. CD10 expression in renal cell carcinoma and endometrial stromal sarcoma may be a useful marker in the differential diagnoses of these tumors because both tumors otherwise lack specific markers.</description><subject>Antigens, Neoplasm</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoembryonic Antigen - analysis</subject><subject>Carcinoma, Renal Cell - chemistry</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Diagnosis, Differential</subject><subject>Endometrial Neoplasms - chemistry</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hematologic Neoplasms - chemistry</subject><subject>Hematologic Neoplasms - pathology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Kidney Neoplasms - chemistry</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidneys</subject><subject>Male</subject><subject>MART-1 Antigen</subject><subject>Medical sciences</subject><subject>Neoplasm Proteins - analysis</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Neprilysin - analysis</subject><subject>Paraffin Embedding</subject><subject>Sarcoma, Endometrial Stromal - chemistry</subject><subject>Sarcoma, Endometrial Stromal - pathology</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1OxDAMhCMEguXnCZBQDlwDTtL0hxtaWEBCggOcV27qiECblqS7gtfgiSliERfPyP7Gh2HsWMKZ1FCdl2tci1flVqK0q0rQmyy32ExWmRZFodQ2mwGAEpUs9B7bT-kVQKoSsl22J6EAU8pyxr4eMaJzPohEdvR94A2NG9c7Pr-SwH3gBgwPfXihDsd-6D2N3vJA_dBi6hK_4ItI7ysKI6ePIVJKP_kpFylgyy2108Bofeg75BgaTqHpOxqjn85pjNN60omYzCHbcdgmOtroAXteXD_Nb8X9w83d_PJeWGXMKDAjLSVpUwC4BmsLLldZbQxgludYNE0uJWZGVwSlqbRUOWo0tay1rB0W-oCd_P4dVnVHzXKIvsP4ufwrZwJONwAmi62LGKxP_9xPmYXS38Ssd7k</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>PEIGUO CHU</creator><creator>ARBER, D. A</creator><general>American Society of Clinical Pathologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20000301</creationdate><title>Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms : Frequent expression in renal cell carcinoma and endometrial stromal sarcoma</title><author>PEIGUO CHU ; ARBER, D. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c255t-a4e311e35700fdabc0f624b550a466a7dd611a4539e08593126a3a5b1b31bfa73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Antigens, Neoplasm</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoembryonic Antigen - analysis</topic><topic>Carcinoma, Renal Cell - chemistry</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Diagnosis, Differential</topic><topic>Endometrial Neoplasms - chemistry</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hematologic Neoplasms - chemistry</topic><topic>Hematologic Neoplasms - pathology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Kidney Neoplasms - chemistry</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidneys</topic><topic>Male</topic><topic>MART-1 Antigen</topic><topic>Medical sciences</topic><topic>Neoplasm Proteins - analysis</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Neprilysin - analysis</topic><topic>Paraffin Embedding</topic><topic>Sarcoma, Endometrial Stromal - chemistry</topic><topic>Sarcoma, Endometrial Stromal - pathology</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PEIGUO CHU</creatorcontrib><creatorcontrib>ARBER, D. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PEIGUO CHU</au><au>ARBER, D. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms : Frequent expression in renal cell carcinoma and endometrial stromal sarcoma</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>113</volume><issue>3</issue><spage>374</spage><epage>382</epage><pages>374-382</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>We tested 505 cases of nonhematopoietic neoplasms by immunohistochemistry using a newly characterized monoclonal antibody (clone 56C6) against the CD10 antigen. CD10 was expressed widely in neoplasms of the genitourinary tract, including 41 (89%) of 46 cases of renal cell carcinoma, 13 (54%) of 24 cases of transitional cell carcinoma, and 11 (61%) of 18 cases of prostatic adenocarcinoma. In addition, 5 (100%) of 5 endometrial stromal sarcomas, 3 (60%) of 5 rhabdomyosarcomas, 7 (50%) of 14 pancreatic adenocarcinomas, 5 (45%) of 11 cases of schwannoma, and 12 (40%) of 30 cases of malignant melanoma also were positive for CD10. Similar to normal tissue, CD10 positivity was restricted to the apical surface of malignant glandular cells of well-differentiated colonic, pancreatic, and prostatic adenocarcinoma, whereas in poorly differentiated adenocarcinoma and other tumors, such as melanoma, transitional cell carcinoma, renal cell carcinoma, and endometrial stromal sarcoma, the CD10 positivity showed diffuse cytoplasmic or membranous/Golgi patterns. The monoclonal antibody clone 56C6 is a reliable marker for CD10 in paraffin immunohistochemistry after heat-induced epitope retrieval. CD10 expression in renal cell carcinoma and endometrial stromal sarcoma may be a useful marker in the differential diagnoses of these tumors because both tumors otherwise lack specific markers.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>10705818</pmid><doi>10.1309/8vav-j2fu-8cu9-ek18</doi><tpages>9</tpages></addata></record> |
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source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
subjects | Antigens, Neoplasm Biological and medical sciences Biomarkers, Tumor - analysis Carcinoembryonic Antigen - analysis Carcinoma, Renal Cell - chemistry Carcinoma, Renal Cell - pathology Diagnosis, Differential Endometrial Neoplasms - chemistry Endometrial Neoplasms - pathology Female Female genital diseases Gynecology. Andrology. Obstetrics Hematologic Neoplasms - chemistry Hematologic Neoplasms - pathology Humans Immunoenzyme Techniques Kidney Neoplasms - chemistry Kidney Neoplasms - pathology Kidneys Male MART-1 Antigen Medical sciences Neoplasm Proteins - analysis Nephrology. Urinary tract diseases Neprilysin - analysis Paraffin Embedding Sarcoma, Endometrial Stromal - chemistry Sarcoma, Endometrial Stromal - pathology Tumors Tumors of the urinary system |
title | Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms : Frequent expression in renal cell carcinoma and endometrial stromal sarcoma |
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