Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms : Frequent expression in renal cell carcinoma and endometrial stromal sarcoma

We tested 505 cases of nonhematopoietic neoplasms by immunohistochemistry using a newly characterized monoclonal antibody (clone 56C6) against the CD10 antigen. CD10 was expressed widely in neoplasms of the genitourinary tract, including 41 (89%) of 46 cases of renal cell carcinoma, 13 (54%) of 24 c...

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Veröffentlicht in:American journal of clinical pathology 2000-03, Vol.113 (3), p.374-382
Hauptverfasser: PEIGUO CHU, ARBER, D. A
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ARBER, D. A
description We tested 505 cases of nonhematopoietic neoplasms by immunohistochemistry using a newly characterized monoclonal antibody (clone 56C6) against the CD10 antigen. CD10 was expressed widely in neoplasms of the genitourinary tract, including 41 (89%) of 46 cases of renal cell carcinoma, 13 (54%) of 24 cases of transitional cell carcinoma, and 11 (61%) of 18 cases of prostatic adenocarcinoma. In addition, 5 (100%) of 5 endometrial stromal sarcomas, 3 (60%) of 5 rhabdomyosarcomas, 7 (50%) of 14 pancreatic adenocarcinomas, 5 (45%) of 11 cases of schwannoma, and 12 (40%) of 30 cases of malignant melanoma also were positive for CD10. Similar to normal tissue, CD10 positivity was restricted to the apical surface of malignant glandular cells of well-differentiated colonic, pancreatic, and prostatic adenocarcinoma, whereas in poorly differentiated adenocarcinoma and other tumors, such as melanoma, transitional cell carcinoma, renal cell carcinoma, and endometrial stromal sarcoma, the CD10 positivity showed diffuse cytoplasmic or membranous/Golgi patterns. The monoclonal antibody clone 56C6 is a reliable marker for CD10 in paraffin immunohistochemistry after heat-induced epitope retrieval. CD10 expression in renal cell carcinoma and endometrial stromal sarcoma may be a useful marker in the differential diagnoses of these tumors because both tumors otherwise lack specific markers.
doi_str_mv 10.1309/8vav-j2fu-8cu9-ek18
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Obstetrics</subject><subject>Hematologic Neoplasms - chemistry</subject><subject>Hematologic Neoplasms - pathology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Kidney Neoplasms - chemistry</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidneys</subject><subject>Male</subject><subject>MART-1 Antigen</subject><subject>Medical sciences</subject><subject>Neoplasm Proteins - analysis</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Neprilysin - analysis</subject><subject>Paraffin Embedding</subject><subject>Sarcoma, Endometrial Stromal - chemistry</subject><subject>Sarcoma, Endometrial Stromal - pathology</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1OxDAMhCMEguXnCZBQDlwDTtL0hxtaWEBCggOcV27qiECblqS7gtfgiSliERfPyP7Gh2HsWMKZ1FCdl2tci1flVqK0q0rQmyy32ExWmRZFodQ2mwGAEpUs9B7bT-kVQKoSsl22J6EAU8pyxr4eMaJzPohEdvR94A2NG9c7Pr-SwH3gBgwPfXihDsd-6D2N3vJA_dBi6hK_4ItI7ysKI6ePIVJKP_kpFylgyy2108Bofeg75BgaTqHpOxqjn85pjNN60omYzCHbcdgmOtroAXteXD_Nb8X9w83d_PJeWGXMKDAjLSVpUwC4BmsLLldZbQxgludYNE0uJWZGVwSlqbRUOWo0tay1rB0W-oCd_P4dVnVHzXKIvsP4ufwrZwJONwAmi62LGKxP_9xPmYXS38Ssd7k</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>PEIGUO CHU</creator><creator>ARBER, D. 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A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c255t-a4e311e35700fdabc0f624b550a466a7dd611a4539e08593126a3a5b1b31bfa73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Antigens, Neoplasm</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoembryonic Antigen - analysis</topic><topic>Carcinoma, Renal Cell - chemistry</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Diagnosis, Differential</topic><topic>Endometrial Neoplasms - chemistry</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hematologic Neoplasms - chemistry</topic><topic>Hematologic Neoplasms - pathology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Kidney Neoplasms - chemistry</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidneys</topic><topic>Male</topic><topic>MART-1 Antigen</topic><topic>Medical sciences</topic><topic>Neoplasm Proteins - analysis</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Neprilysin - analysis</topic><topic>Paraffin Embedding</topic><topic>Sarcoma, Endometrial Stromal - chemistry</topic><topic>Sarcoma, Endometrial Stromal - pathology</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PEIGUO CHU</creatorcontrib><creatorcontrib>ARBER, D. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PEIGUO CHU</au><au>ARBER, D. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms : Frequent expression in renal cell carcinoma and endometrial stromal sarcoma</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>113</volume><issue>3</issue><spage>374</spage><epage>382</epage><pages>374-382</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>We tested 505 cases of nonhematopoietic neoplasms by immunohistochemistry using a newly characterized monoclonal antibody (clone 56C6) against the CD10 antigen. CD10 was expressed widely in neoplasms of the genitourinary tract, including 41 (89%) of 46 cases of renal cell carcinoma, 13 (54%) of 24 cases of transitional cell carcinoma, and 11 (61%) of 18 cases of prostatic adenocarcinoma. In addition, 5 (100%) of 5 endometrial stromal sarcomas, 3 (60%) of 5 rhabdomyosarcomas, 7 (50%) of 14 pancreatic adenocarcinomas, 5 (45%) of 11 cases of schwannoma, and 12 (40%) of 30 cases of malignant melanoma also were positive for CD10. Similar to normal tissue, CD10 positivity was restricted to the apical surface of malignant glandular cells of well-differentiated colonic, pancreatic, and prostatic adenocarcinoma, whereas in poorly differentiated adenocarcinoma and other tumors, such as melanoma, transitional cell carcinoma, renal cell carcinoma, and endometrial stromal sarcoma, the CD10 positivity showed diffuse cytoplasmic or membranous/Golgi patterns. The monoclonal antibody clone 56C6 is a reliable marker for CD10 in paraffin immunohistochemistry after heat-induced epitope retrieval. CD10 expression in renal cell carcinoma and endometrial stromal sarcoma may be a useful marker in the differential diagnoses of these tumors because both tumors otherwise lack specific markers.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>10705818</pmid><doi>10.1309/8vav-j2fu-8cu9-ek18</doi><tpages>9</tpages></addata></record>
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source Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Antigens, Neoplasm
Biological and medical sciences
Biomarkers, Tumor - analysis
Carcinoembryonic Antigen - analysis
Carcinoma, Renal Cell - chemistry
Carcinoma, Renal Cell - pathology
Diagnosis, Differential
Endometrial Neoplasms - chemistry
Endometrial Neoplasms - pathology
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Hematologic Neoplasms - chemistry
Hematologic Neoplasms - pathology
Humans
Immunoenzyme Techniques
Kidney Neoplasms - chemistry
Kidney Neoplasms - pathology
Kidneys
Male
MART-1 Antigen
Medical sciences
Neoplasm Proteins - analysis
Nephrology. Urinary tract diseases
Neprilysin - analysis
Paraffin Embedding
Sarcoma, Endometrial Stromal - chemistry
Sarcoma, Endometrial Stromal - pathology
Tumors
Tumors of the urinary system
title Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms : Frequent expression in renal cell carcinoma and endometrial stromal sarcoma
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