Inflammatory action of 8-methoxypsoralen-spermine photoproduct (8-MOP-Spm-P(GFC)) and effects of various drugs on rat paw edema induced by 8-MOP-Spm-P(GFC)

The photoproducts produced by irradiating 8-methoxypsoralen (8-MOP) in the presence of spermine (Spm) were fractionated using gel filtration chromatography (GFC) on a Sephadex G-25 column. As a result, two bands which were characterized by the effects on hyaluronidase activity were obtained. The fir...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1999-11, Vol.22 (11), p.1202
Hauptverfasser:	Shigehara, N, Miyataka, H, Kakegawa, H, Nishiki, M, Matsumoto, H, Isobe, A, Satoh, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Edema - chemically induced Edema - drug therapy Erythrocytes - drug effects Erythrocytes - enzymology Hemolysis - drug effects Histamine Antagonists - pharmacology Hyaluronoglucosaminidase - chemistry Hydrogen-Ion Concentration L-Lactate Dehydrogenase - metabolism Male Methoxsalen - chemistry Methoxsalen - toxicity Molecular Weight Rats Rats, Sprague-Dawley Spermine - chemistry Spermine - toxicity
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Zusammenfassung:	The photoproducts produced by irradiating 8-methoxypsoralen (8-MOP) in the presence of spermine (Spm) were fractionated using gel filtration chromatography (GFC) on a Sephadex G-25 column. As a result, two bands which were characterized by the effects on hyaluronidase activity were obtained. The first band strongly activated the hyaluronidase, but a second band did not exhibit any effect on the enzyme activity. The first and second bands contained photoproducts with molecular weights (MW)>2700 and MW
ISSN:	0918-6158
DOI:	10.1248/bpb.22.1202