Biologically Active Carbazole Alkaloids from Murraya koenigii

The bioassay guided fractionation of the acetone extract of the fresh leaves of Murraya koenigii resulted in the isolation of three bioactive carbazole alkaloids, mahanimbine (1), murrayanol (2), and mahanine (3), as confirmed from their (1)H and (13)C NMR spectral data. Compound 2 showed an IC(50)...

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Veröffentlicht in:	Journal of agricultural and food chemistry 1999-02, Vol.47 (2), p.444-447
Hauptverfasser:	RAMSEWAK, Russel S., NAIR, Muraleedharan G., STRASBURG, Gale M., DEWITT, David L., NITISS, John L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aedes Alkaloids - isolation & purification Alkaloids - pharmacology Animals Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antioxidants - isolation & purification Antioxidants - pharmacology Bacteria - drug effects Biological and medical sciences Carbazoles - isolation & purification Carbazoles - pharmacology Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Food additives Food industries Fundamental and applied biological sciences. Psychology General aspects General pharmacology Humans Insecticides - isolation & purification Magnetic Resonance Spectroscopy Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Plants, Medicinal - chemistry Topoisomerase I Inhibitors Topoisomerase II Inhibitors
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Beschreibung
Zusammenfassung:	The bioassay guided fractionation of the acetone extract of the fresh leaves of Murraya koenigii resulted in the isolation of three bioactive carbazole alkaloids, mahanimbine (1), murrayanol (2), and mahanine (3), as confirmed from their (1)H and (13)C NMR spectral data. Compound 2 showed an IC(50) of 109 microg/mL against hPGHS-1 and an IC(50) of 218 microg/mL against hPGHS-2 in antiinflammatory assays, while compound 1 displayed antioxidant activity at 33.1 microg/mL. All three compounds were mosquitocidal and antimicrobial and exhibited topoisomerase I and II inhibition activities.
ISSN:	0021-8561 1520-5118
DOI:	10.1021/jf9805808