The Late Phase of Ischemic Preconditioning Is Abrogated by Targeted Disruption of the Inducible NO Synthase Gene

The goal of this study was to interrogate the role of inducible NO synthase (iNOS) in the late phase of ischemic preconditioning (PC) in vivo. A total of 321 mice were used. Wild-type mice preconditioned 24 h earlier with six cycles of 4-min coronary occlusion/4-min reperfusion exhibited a significa...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-09, Vol.96 (20), p.11507-11512
Hauptverfasser:	Guo, Y, Jones, W K, Xuan, Y T, Tang, X L, Bao, W, Wu, W J, Han, H, Laubach, V E, Ping, P, Yang, Z, Qiu, Y, Bolli, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Body Temperature citrulline Heart Rate Ischemic Preconditioning Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Myocardial Infarction - etiology Myocardial reperfusion Nitrates Nitric Oxide Synthase - genetics Nitric Oxide Synthase - physiology Nitric Oxide Synthase Type II Nitrites NOS gene Pharmacology Protein isoforms Protein synthesis Tissue samples Up regulation
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Zusammenfassung:	The goal of this study was to interrogate the role of inducible NO synthase (iNOS) in the late phase of ischemic preconditioning (PC) in vivo. A total of 321 mice were used. Wild-type mice preconditioned 24 h earlier with six cycles of 4-min coronary occlusion/4-min reperfusion exhibited a significant$(P
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.96.20.11507