Synthetic Studies on 2′-Substituted-4′-thiocytidine Derivatives as Antineoplastic Agents

As potential antineoplastic agents, we have synthesized 4′-thioFAC and 4′-thiocytarazid by developing an alternative synthetic method. 4′-ThioFAC showed potent antineoplastic activities in vivo as well as in vitro.

Bibliographische Detailangaben

Veröffentlicht in:	Nucleosides & nucleotides 1999-04, Vol.18 (4-5), p.815-820
Hauptverfasser:	Yoshimura, Yuichi, Endo, Mikari, Kitano, Kenji, Yamada, Kohei, Sakata, Shinji, Miura, Shinji, Machida, Haruhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Cytidine - chemistry Humans Mice Mice, Nude Thionucleosides - chemical synthesis Tumor Cells, Cultured
Online-Zugang:	Volltext
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