Synthetic Studies on 2′-Substituted-4′-thiocytidine Derivatives as Antineoplastic Agents

Synthetic Studies on 2′-Substituted-4′-thiocytidine Derivatives as Antineoplastic Agents

As potential antineoplastic agents, we have synthesized 4′-thioFAC and 4′-thiocytarazid by developing an alternative synthetic method. 4′-ThioFAC showed potent antineoplastic activities in vivo as well as in vitro.

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Bibliographische Detailangaben
Veröffentlicht in:Nucleosides & nucleotides 1999-04, Vol.18 (4-5), p.815-820
Hauptverfasser: Yoshimura, Yuichi, Endo, Mikari, Kitano, Kenji, Yamada, Kohei, Sakata, Shinji, Miura, Shinji, Machida, Haruhiko
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antineoplastic Agents - chemical synthesis
Cytidine - chemistry
Humans
Mice
Mice, Nude
Thionucleosides - chemical synthesis
Tumor Cells, Cultured
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Zusammenfassung:As potential antineoplastic agents, we have synthesized 4′-thioFAC and 4′-thiocytarazid by developing an alternative synthetic method. 4′-ThioFAC showed potent antineoplastic activities in vivo as well as in vitro.
ISSN:0732-8311
DOI:10.1080/15257779908041569