Non-Polypoid Adenomas of the Colon Are Associated with Subjacent Lymphoid Nodules: An Experimental Study in Rats
Background: Subjacent lymphoid nodules (SLNs) have been found in 38% of non-polypoid colonic adenomas in humans. In the present work the presence of SLNs in experimentally induced colonic adenomas was investigated in rats. Methods: 1,2-Dimethylhydrazine was injected subcutaneously in 290 Sprague-Daw...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1999, Vol.34 (5), p.504-508 |
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| creator | RUBIO, C. A SHETYE, J JARAMILLO, E |
| description | Background: Subjacent lymphoid nodules (SLNs) have been found in 38% of non-polypoid colonic adenomas in humans. In the present work the presence of SLNs in experimentally induced colonic adenomas was investigated in rats. Methods: 1,2-Dimethylhydrazine was injected subcutaneously in 290 Sprague-Dawley rats for 27 weeks. Results: An SLN was present in 28.6% of the 84 adenomas, in 8.4% of the 119 adenocarcinomas, and in 9.7% of the 31 small carcinomas without remnant adenomatous tissue. An SLN was found in 35.6% of the 59 non-polypoid neoplasias but only in 9.1% of the 175 polypoid (that is, exophytic) neoplasias. When only adenomas were considered, SLNs were present in 50.0% of the 34 non-polypoid adenomas but only in 14.0% of the 50 polypoid adenomas. Conclusions: Non-polypoid colonic adenomas evolve preferentially from the minimal fraction of the colonic mucosa that overlays the few existing lymphoid nodules in rats. |
| doi_str_mv | 10.1080/003655299750026245 |
| format | Article |
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A ; SHETYE, J ; JARAMILLO, E</creator><creatorcontrib>RUBIO, C. A ; SHETYE, J ; JARAMILLO, E</creatorcontrib><description>Background: Subjacent lymphoid nodules (SLNs) have been found in 38% of non-polypoid colonic adenomas in humans. In the present work the presence of SLNs in experimentally induced colonic adenomas was investigated in rats. Methods: 1,2-Dimethylhydrazine was injected subcutaneously in 290 Sprague-Dawley rats for 27 weeks. Results: An SLN was present in 28.6% of the 84 adenomas, in 8.4% of the 119 adenocarcinomas, and in 9.7% of the 31 small carcinomas without remnant adenomatous tissue. An SLN was found in 35.6% of the 59 non-polypoid neoplasias but only in 9.1% of the 175 polypoid (that is, exophytic) neoplasias. When only adenomas were considered, SLNs were present in 50.0% of the 34 non-polypoid adenomas but only in 14.0% of the 50 polypoid adenomas. Conclusions: Non-polypoid colonic adenomas evolve preferentially from the minimal fraction of the colonic mucosa that overlays the few existing lymphoid nodules in rats.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.1080/003655299750026245</identifier><identifier>PMID: 10423067</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Informa UK Ltd</publisher><subject>Adenoma - pathology ; Animals ; Biological and medical sciences ; Colonic Neoplasms - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Lymphoid Tissue - pathology ; Male ; Medical sciences ; Rats ; Rats, Sprague-Dawley ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Scandinavian journal of gastroenterology, 1999, Vol.34 (5), p.504-508</ispartof><rights>1999 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-88bf37b7f72aa2e6d9dcf07959759dd292f550c45b3dbbaa17ca5d740e73df23</citedby><cites>FETCH-LOGICAL-c473t-88bf37b7f72aa2e6d9dcf07959759dd292f550c45b3dbbaa17ca5d740e73df23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/003655299750026245$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/003655299750026245$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>230,314,776,780,881,4009,27902,27903,27904,59623,59729,60412,60518,61197,61232,61378,61413</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1857664$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10423067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1939884$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>RUBIO, C. A</creatorcontrib><creatorcontrib>SHETYE, J</creatorcontrib><creatorcontrib>JARAMILLO, E</creatorcontrib><title>Non-Polypoid Adenomas of the Colon Are Associated with Subjacent Lymphoid Nodules: An Experimental Study in Rats</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Background: Subjacent lymphoid nodules (SLNs) have been found in 38% of non-polypoid colonic adenomas in humans. In the present work the presence of SLNs in experimentally induced colonic adenomas was investigated in rats. Methods: 1,2-Dimethylhydrazine was injected subcutaneously in 290 Sprague-Dawley rats for 27 weeks. Results: An SLN was present in 28.6% of the 84 adenomas, in 8.4% of the 119 adenocarcinomas, and in 9.7% of the 31 small carcinomas without remnant adenomatous tissue. An SLN was found in 35.6% of the 59 non-polypoid neoplasias but only in 9.1% of the 175 polypoid (that is, exophytic) neoplasias. When only adenomas were considered, SLNs were present in 50.0% of the 34 non-polypoid adenomas but only in 14.0% of the 50 polypoid adenomas. Conclusions: Non-polypoid colonic adenomas evolve preferentially from the minimal fraction of the colonic mucosa that overlays the few existing lymphoid nodules in rats.</description><subject>Adenoma - pathology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Colonic Neoplasms - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Lymphoid Tissue - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV2L1DAUhoMo7rj6B7yQXIh31TRtmkbcizKsHzCs4u59Oc0H0zFNatIy9t-boeMXwl4lJM_zcg4vQs9z8jonNXlDSFExRoXgjBBa0ZI9QJucEZpxTuqHaHMCskTkF-hJjAdCCOOleIwuclLSglR8g8Yb77Iv3i6j7xVulHZ-gIi9wdNe46233uEmaNzE6GUPk1b42E97fDt3B5DaTXi3DOP-JN94NVsd3-LG4esfow79kP7B4ttpVgvuHf4KU3yKHhmwUT87n5fo7v313fZjtvv84dO22WWy5MWU1XVnCt5xwykA1ZUSShrCBUvLCqWooIYxIkvWFarrAHIugSleEs0LZWhxibI1Nh71OHftmKaBsLQe-vb89C3ddFuRktd14l-t_Bj891nHqR36KLW14LSfY1sJQUtRnEC6gjL4GIM2v6Nz0p5qaf-vJUkvzulzN2j1l7L2kICXZwCiBGsCONnHP1zNeFWVCbtasd4ZHwY4-mBVO8FiffjlFPfO8e4ff6_BTnsJQbcHPweXCrlvjZ_MLLud</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>RUBIO, C. A</creator><creator>SHETYE, J</creator><creator>JARAMILLO, E</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>1999</creationdate><title>Non-Polypoid Adenomas of the Colon Are Associated with Subjacent Lymphoid Nodules: An Experimental Study in Rats</title><author>RUBIO, C. A ; SHETYE, J ; JARAMILLO, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-88bf37b7f72aa2e6d9dcf07959759dd292f550c45b3dbbaa17ca5d740e73df23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adenoma - pathology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Colonic Neoplasms - pathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Lymphoid Tissue - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RUBIO, C. A</creatorcontrib><creatorcontrib>SHETYE, J</creatorcontrib><creatorcontrib>JARAMILLO, E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RUBIO, C. A</au><au>SHETYE, J</au><au>JARAMILLO, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-Polypoid Adenomas of the Colon Are Associated with Subjacent Lymphoid Nodules: An Experimental Study in Rats</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1999</date><risdate>1999</risdate><volume>34</volume><issue>5</issue><spage>504</spage><epage>508</epage><pages>504-508</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>Background: Subjacent lymphoid nodules (SLNs) have been found in 38% of non-polypoid colonic adenomas in humans. In the present work the presence of SLNs in experimentally induced colonic adenomas was investigated in rats. Methods: 1,2-Dimethylhydrazine was injected subcutaneously in 290 Sprague-Dawley rats for 27 weeks. Results: An SLN was present in 28.6% of the 84 adenomas, in 8.4% of the 119 adenocarcinomas, and in 9.7% of the 31 small carcinomas without remnant adenomatous tissue. An SLN was found in 35.6% of the 59 non-polypoid neoplasias but only in 9.1% of the 175 polypoid (that is, exophytic) neoplasias. When only adenomas were considered, SLNs were present in 50.0% of the 34 non-polypoid adenomas but only in 14.0% of the 50 polypoid adenomas. Conclusions: Non-polypoid colonic adenomas evolve preferentially from the minimal fraction of the colonic mucosa that overlays the few existing lymphoid nodules in rats.</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>10423067</pmid><doi>10.1080/003655299750026245</doi><tpages>5</tpages></addata></record> |
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| ispartof | Scandinavian journal of gastroenterology, 1999, Vol.34 (5), p.504-508 |
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| source | MEDLINE; Taylor & Francis; Taylor & Francis Medical Library - CRKN |
| subjects | Adenoma - pathology Animals Biological and medical sciences Colonic Neoplasms - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Lymphoid Tissue - pathology Male Medical sciences Rats Rats, Sprague-Dawley Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Non-Polypoid Adenomas of the Colon Are Associated with Subjacent Lymphoid Nodules: An Experimental Study in Rats |
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