Non-Polypoid Adenomas of the Colon Are Associated with Subjacent Lymphoid Nodules: An Experimental Study in Rats
Background: Subjacent lymphoid nodules (SLNs) have been found in 38% of non-polypoid colonic adenomas in humans. In the present work the presence of SLNs in experimentally induced colonic adenomas was investigated in rats. Methods: 1,2-Dimethylhydrazine was injected subcutaneously in 290 Sprague-Daw...
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Veröffentlicht in: | Scandinavian journal of gastroenterology 1999, Vol.34 (5), p.504-508 |
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Sprache: | eng |
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Zusammenfassung: | Background: Subjacent lymphoid nodules (SLNs) have been found in 38% of non-polypoid colonic adenomas in humans. In the present work the presence of SLNs in experimentally induced colonic adenomas was investigated in rats. Methods: 1,2-Dimethylhydrazine was injected subcutaneously in 290 Sprague-Dawley rats for 27 weeks. Results: An SLN was present in 28.6% of the 84 adenomas, in 8.4% of the 119 adenocarcinomas, and in 9.7% of the 31 small carcinomas without remnant adenomatous tissue. An SLN was found in 35.6% of the 59 non-polypoid neoplasias but only in 9.1% of the 175 polypoid (that is, exophytic) neoplasias. When only adenomas were considered, SLNs were present in 50.0% of the 34 non-polypoid adenomas but only in 14.0% of the 50 polypoid adenomas. Conclusions: Non-polypoid colonic adenomas evolve preferentially from the minimal fraction of the colonic mucosa that overlays the few existing lymphoid nodules in rats. |
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ISSN: | 0036-5521 1502-7708 |
DOI: | 10.1080/003655299750026245 |