Intradermal irritation of dental bleaching agents in rats

To evaluate the irritative potential of three dental bleaching agents (hydrogen oxide, carbopol, and carbamide peroxide). In rats, Evans blue (2.5%, 1 mL.L-1) was injected i.v. and later each test solution was injected intradermally on the back. After the concentration of the dye in the stained skin...

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Veröffentlicht in:	Zhōngguó yàolĭ xuébào 1998-09, Vol.19 (5), p.422
Hauptverfasser:	Gonçalves, C E, Tokano-Ramos, L V, Pasccoto, R C, Bersani-Amado, C A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins Animals Capillary Permeability - drug effects Dermatitis, Irritant - etiology Drug Combinations Hydrogen Peroxide - adverse effects Injections, Intradermal Male Peroxides - adverse effects Polyvinyls - adverse effects Rats Rats, Wistar Tooth Bleaching Urea - adverse effects Urea - analogs & derivatives
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Beschreibung
Zusammenfassung:	To evaluate the irritative potential of three dental bleaching agents (hydrogen oxide, carbopol, and carbamide peroxide). In rats, Evans blue (2.5%, 1 mL.L-1) was injected i.v. and later each test solution was injected intradermally on the back. After the concentration of the dye in the stained skin area was determined by spectrophotometric analysis. All the dental bleaching agents caused increase of vascular permeability and the intensity varied with the time. Dental bleach agents had a great potential for irritating soft tissues.
ISSN:	0253-9756