Relationship of Neonatal Withdrawal to Maternal Methadone Dose

Neonatal withdrawal is described for a sample of 70 infants born to addicted women treated with methadone and comprehensive prenatal care. Although symptoms were manifested by over 90% of the infants, those born to women receiving near-term average doses of ≤20 mg/day had significantly less symptoma...

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Veröffentlicht in:	The American journal of drug and alcohol abuse 1976, Vol.3 (2), p.339-345
Hauptverfasser:	Strauss, M. E., Andresko, M., Stryker, J. C., Wardell, J. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Female Heroin Dependence - rehabilitation Humans Infant, Newborn Infant, Newborn, Diseases - etiology Male Methadone - administration & dosage Methadone - adverse effects Methadone - therapeutic use Pregnancy Substance Withdrawal Syndrome - epidemiology Substance Withdrawal Syndrome - etiology Time Factors
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Beschreibung
Zusammenfassung:	Neonatal withdrawal is described for a sample of 70 infants born to addicted women treated with methadone and comprehensive prenatal care. Although symptoms were manifested by over 90% of the infants, those born to women receiving near-term average doses of ≤20 mg/day had significantly less symptomatology, weight loss, and need for pharmacologic treatment than those of mothers still on higher doses. Reduction of methadone dose levels during the last 6 weeks of pregnancy to ≤20 mg/day appears to reduce the severity of neonatal withdrawal.
ISSN:	0095-2990 1097-9891
DOI:	10.3109/00952997609077202