Rapidly acquired cytotoxicity of lymphoid cells from ice inoculated with allogeneic spleen cells

Spleen cells from C57BL/6J or CBA mice inoculated iv with spleen cells from BALB/c mice produced a strong nonspecific cytotoxic effect on target cells (mouse L-cells). Lymph node cells from CBA or C57BL/6J mice inoculated sc with BALB/c spleen cells also destroyed L-cells. Lymph node cells from mice...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1976-12, Vol.57 (6), p.1233
Hauptverfasser:	Slavina, E G, Karmanova, N V, Leipunskaya, I L, Zinzar, S N, Reinhöfer, J, Svet-Moldavsky, G J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Cytotoxicity Tests, Immunologic Female Interferons - biosynthesis Interferons - immunology Lymph Nodes - immunology Lymphocytes - immunology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Spleen - immunology Time Factors Transplantation, Homologous Transplantation, Isogeneic
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Beschreibung
Zusammenfassung:	Spleen cells from C57BL/6J or CBA mice inoculated iv with spleen cells from BALB/c mice produced a strong nonspecific cytotoxic effect on target cells (mouse L-cells). Lymph node cells from CBA or C57BL/6J mice inoculated sc with BALB/c spleen cells also destroyed L-cells. Lymph node cells from mice inoculated with syngeneic spleen cells were not cytotoxic. The cytotoxic effect was observed ion of allogeneic but not syngeneic spleen cells. This effect was considerably reduced or completely suppressed after partial or total removal of plastic-adherent cells.
ISSN:	0027-8874