NEUTROPHIL INFLUX AND MIGRATION IN RABBIT AIRWAYS IN RESPONSE TO STAPHYLOCOCCAL ENTEROTOXIN-A

Single-cycle lavages performed on the lungs of rabbits 7 hours after they received intravenous staphylococcal enterotoxin-A (SEA) showed that most of the neutrophils were found in the second of 5 fractions of fluid removed from the lungs. To determine whether this finding reflected an accumulation o...

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Veröffentlicht in:	Experimental lung research 1999, Vol.25 (1), p.41-54
1. Verfasser:	Peterson, Barry T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Lavage Lungs Animals Bacterial diseases Biological and medical sciences Bronchi - cytology Bronchi - drug effects Bronchoalveolar Lavage Cell Movement - drug effects Enterotoxins - pharmacology Experimental bacterial diseases and models Infectious diseases Lung - cytology Lung - drug effects Medical sciences Neutrophils - drug effects Neutrophils - physiology Pulmonary Alveoli - cytology Pulmonary Alveoli - drug effects Rabbits Staphylococcus aureus Time Factors Trachea - cytology Trachea - drug effects
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Zusammenfassung:	Single-cycle lavages performed on the lungs of rabbits 7 hours after they received intravenous staphylococcal enterotoxin-A (SEA) showed that most of the neutrophils were found in the second of 5 fractions of fluid removed from the lungs. To determine whether this finding reflected an accumulation of neutrophils in the airways versus the alveolar regions of the lungs, we counted the neutrophils in histologic sections (20 microns) and estimated the concentration of neutrophils in the epithelial lining fluid of the airways versus the alveoli. Comparisons of the morphometric measurements and the lavage data showed a strong correlation between the 2 methods (r=.90, P
ISSN:	0190-2148 1521-0499
DOI:	10.1080/019021499270411