Oral-absorption-enhancing drug-delivery technology

Oral-absorption-enhancing drug-delivery technology

Use of intestinal-absorption enhancers to improve the oral delivery of poorly permeable drug compounds is an important consideration in solid-dosage formulation development. The authors examine an oral-absorption-enhancement technology based on surface-active materials to increase apical membrane fl...

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Veröffentlicht in:Pharmaceutical Technology 2011-04, Vol.35 (4), p.S12
Hauptverfasser: Walsh, Edwin G, Cullen, Alan P, Fox, John S, Leonard, Thomas W
Format: Magazinearticle
Sprache:eng
Schlagworte:
Absorption (Physiology)
Amino acids
Bioavailability
Drug delivery systems
Drug dosages
Drug formularies
Drugs
Gastrointestinal surgery
Glycoproteins
Metabolism
Permeability
Pharmaceutical industry
R&D
Research & development
Small intestine
Surfactants
Vehicles
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Zusammenfassung:Use of intestinal-absorption enhancers to improve the oral delivery of poorly permeable drug compounds is an important consideration in solid-dosage formulation development. The authors examine an oral-absorption-enhancement technology based on surface-active materials to increase apical membrane fluidity in vitro and to increase in vivo the transcellular transport of normally excluded molecules. [PUBLICATION ABSTRACT]
ISSN:1543-2521
2150-7376