Treatment Resistance in Schizophrenia: The Role of Alternative Therapies

A page was turned when Kane and associates8 published results from a landmark study of clozapine that demonstrated real hope for persons with treatment-resistant symptoms associated with schizophrenia. The researchers used a demanding operationalized definition of treatment resistance for the study that included significant psychotic pathology in the face of at least 3 unsuccessful trials of different neuroleptics at high doses for a minimum of 6 weeks in the previous 5 years.