Detection of Cache Valley Virus in biologics manufactured in CHO cells

Detection of Cache Valley Virus in biologics manufactured in CHO cells

Cache Valley virus (CVV) is one of relatively few viruses found to contaminate biologics manufactured in Chinese hamster ovary cells. This member of the Bunyaviridae family infects livestock throughout North America, and is believed to enter the biologics production processes through contaminated fe...

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Veröffentlicht in:Biopharm International 2008-10, Vol.21 (10), p.89
Hauptverfasser: Nims, Raymond W, Dusing, Sandra K, Hsieh, Wang-Ting, Lovatt, Archie, Reid, G. Gordon, Onions, David, Milne, Euan W
Format: Magazinearticle
Sprache:eng
Schlagworte:
Atoms & subatomic particles
Biological products
Biological products industry
Biopharmaceutics
Cell growth
Chemicals
Contamination
Detectors
Encephalitis
Health aspects
Immunization
Infection
Infections
Manufacturing
Meningitis
Monoclonal antibodies
Ovaries
Particle size
Pollutants
Sensors
Slopes (Physical geography)
Viral infections
Viruses
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Zusammenfassung:Cache Valley virus (CVV) is one of relatively few viruses found to contaminate biologics manufactured in Chinese hamster ovary cells. This member of the Bunyaviridae family infects livestock throughout North America, and is believed to enter the biologics production processes through contaminated fetal bovine serum used in the cell growth medium. We describe the detection of CVV in Chinese hamster ovary cell-derived biologics over a 10-year period. [PUBLICATION ABSTRACT]
ISSN:1542-166X
1939-1862