Think Like a Scientist-Behave Like a Business

Through the judicious use of functional-area committees and agenda-driven membership review, we were able to reduce by half the number of executives required to serve on the CMC Review Committee (Figure 1).\n * As a result of several improvements-the application of platform technologies, an increase in pilot-plant capacity, and advances in technology - the number of transient cell lines produced for research and the number of stable cell lines have significantly increased per full-time employee. * By changing the stringency of methotrexate treatment earlier in cell-line development and developing serum-free cell lines, several months have been trimmed off the cell-banking critical path.