The Versatility of Portable Raman in Process Development

For the first reaction of the synthesis of 2-phenylimidazo[1,2-a]pyridine, a spectrum was taken for each of the starting materials and the final product to identify the [Raman] peaks to monitor during the course of the reaction process. As shown in Figure 1, the three regions of interest are 847 cm-1 (2-aminopyridine, reactant 1), 1547 cm-1 (final product), and broad dual peaks between 1684-1702 cm-1 (2-bromoacetophenone, reactant 2).