Deciphering Aromatic Oligoamide Foldamer-DNA Interactions

Deciphering Aromatic Oligoamide Foldamer-DNA Interactions

Finest selection: Side‐chain selective, end‐group selective, diastereoselective, and RNA‐ vs. DNA‐selective interactions have been revealed between multiturn helical aromatic amide foldamers having cationic side chains and G‐quadruplex aptamers.

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Veröffentlicht in:Angewandte Chemie International Edition 2012-01, Vol.51 (2), p.473-477
Hauptverfasser: Delaurière, Laurence, Dong, Zeyuan, Laxmi-Reddy, Katta, Godde, Frédéric, Toulmé, Jean-Jacques, Huc, Ivan
Format: Artikel
Sprache:eng
Schlagworte:
Amides - chemistry
Aptamers, Nucleotide - chemistry
Base Sequence
Circular Dichroism
DNA - chemistry
DNA recognition
foldamers
G-Quadruplexes
Hydrocarbons, Aromatic - chemistry
Models, Molecular
RNA - chemistry
RNA recognition
selex
SELEX Aptamer Technique
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Beschreibung
Zusammenfassung:Finest selection: Side‐chain selective, end‐group selective, diastereoselective, and RNA‐ vs. DNA‐selective interactions have been revealed between multiturn helical aromatic amide foldamers having cationic side chains and G‐quadruplex aptamers.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201106208