Synthesis and Immunostimulating Properties of Novel Adamant-1-yl Tripeptides

The aim of this work was to prepare L‐ and D‐(adamant‐1‐yl)‐Gly‐L‐Ala‐D‐isoGln peptides in order to study their adjuvant (immunostimulating) activities. Adjuvant activity of adamant‐1‐yl tripeptides was tested in the mouse model using ovalbumin as an antigen and in comparison to the peptidoglycan mo...

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Veröffentlicht in:	Chemistry & biodiversity 2012-04, Vol.9 (4), p.777-788
Hauptverfasser:	Ribić, Rosana, Habjanec, Lidija, Vranešić, Branka, Frkanec, Ruža, Tomić, Srđanka
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - chemical synthesis Adamantane - pharmacology Adamantyl tripeptides Adjuvants, Immunologic - chemical synthesis Adjuvants, Immunologic - chemistry Adjuvants, Immunologic - pharmacology Animals Immunostimulating activity Mice Oligopeptides - chemical synthesis Oligopeptides - chemistry Oligopeptides - pharmacology Ovalbumin - immunology Peptides Peptidoglycan - chemistry Peptidoglycan - pharmacology Peptidoglycans
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Beschreibung
Zusammenfassung:	The aim of this work was to prepare L‐ and D‐(adamant‐1‐yl)‐Gly‐L‐Ala‐D‐isoGln peptides in order to study their adjuvant (immunostimulating) activities. Adjuvant activity of adamant‐1‐yl tripeptides was tested in the mouse model using ovalbumin as an antigen and in comparison to the peptidoglycan monomer (PGM; β‐D‐GlcNAc‐(1→4)‐D‐MurNAc‐L‐Ala‐D‐isoGln‐mesoDAP(εNH2)‐D‐Ala‐D‐Ala) and structurally related adamant‐2‐yl tripeptides.
ISSN:	1612-1872 1612-1880
DOI:	10.1002/cbdv.201100232