Copper-Catalyzed Di- and Trifluoromethylation of α,β-Unsaturated Carboxylic Acids: A Protocol for Vinylic Fluoroalkylations

Dual action: The Lewis acid CuF2⋅2 H2O efficiently catalyzes the reaction between electrophilic fluoroalkylating agents and α,β‐unsaturated carboxylic acids by dually activating both reactants, thus affording di‐ and trifluoromethyl alkenes in high yields with excellent E/Z selectivity.

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Veröffentlicht in:	Angewandte Chemie International Edition 2012-04, Vol.51 (16), p.3944-3947
Hauptverfasser:	He, Zhengbiao, Luo, Tao, Hu, Mingyou, Cao, Yanjing, Hu, Jinbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes Alkylation carboxylic acids Carboxylic Acids - chemistry Catalysis copper Copper - chemistry fluorine Fluorine - chemistry stereoselectivity synthetic methods Vinyl Compounds - chemistry
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creator	He, Zhengbiao Luo, Tao Hu, Mingyou Cao, Yanjing Hu, Jinbo
description	Dual action: The Lewis acid CuF2⋅2 H2O efficiently catalyzes the reaction between electrophilic fluoroalkylating agents and α,β‐unsaturated carboxylic acids by dually activating both reactants, thus affording di‐ and trifluoromethyl alkenes in high yields with excellent E/Z selectivity.
doi_str_mv	10.1002/anie.201200140
format	Article
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subjects	Alkenes Alkylation carboxylic acids Carboxylic Acids - chemistry Catalysis copper Copper - chemistry fluorine Fluorine - chemistry stereoselectivity synthetic methods Vinyl Compounds - chemistry
title	Copper-Catalyzed Di- and Trifluoromethylation of α,β-Unsaturated Carboxylic Acids: A Protocol for Vinylic Fluoroalkylations
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