Copper-Catalyzed Di- and Trifluoromethylation of α,β-Unsaturated Carboxylic Acids: A Protocol for Vinylic Fluoroalkylations

Dual action: The Lewis acid CuF2⋅2 H2O efficiently catalyzes the reaction between electrophilic fluoroalkylating agents and α,β‐unsaturated carboxylic acids by dually activating both reactants, thus affording di‐ and trifluoromethyl alkenes in high yields with excellent E/Z selectivity.

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2012-04, Vol.51 (16), p.3944-3947
Hauptverfasser:	He, Zhengbiao, Luo, Tao, Hu, Mingyou, Cao, Yanjing, Hu, Jinbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes Alkylation carboxylic acids Carboxylic Acids - chemistry Catalysis copper Copper - chemistry fluorine Fluorine - chemistry stereoselectivity synthetic methods Vinyl Compounds - chemistry
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Dual action: The Lewis acid CuF2⋅2 H2O efficiently catalyzes the reaction between electrophilic fluoroalkylating agents and α,β‐unsaturated carboxylic acids by dually activating both reactants, thus affording di‐ and trifluoromethyl alkenes in high yields with excellent E/Z selectivity.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201200140