The expression of ferritin, lactoferrin, transferrin receptor and solute carrier family 11A1 in the host response to BCG-vaccination and Mycobacterium tuberculosis challenge

The expression of ferritin, lactoferrin, transferrin receptor and solute carrier family 11A1 in the host response to BCG-vaccination and Mycobacterium tuberculosis challenge

Highlights ► Splenocytes from BCG and naïve guinea pigs were used to study ferritin levels. ► Ferritin was suppressed in vaccine-derived cells after PPD stimulation. ► TNFα and NO were involved in ferritin suppression. ► Microarray revealed suppression of further iron-related genes after M. tubercul...

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Veröffentlicht in:Vaccine 2012-05, Vol.30 (21), p.3159-3168
Hauptverfasser: Thom, R.E, Elmore, M.J, Williams, A, Andrews, S.C, Drobniewski, F, Marsh, P.D, Tree, J.A
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
BCG
BCG Vaccine - immunology
Biomarkers
Cation Transport Proteins - biosynthesis
Cofactors
Ferritin
Ferritins - biosynthesis
Gene expression
Gene Expression Profiling
gene expression regulation
genes
Guinea pig
Guinea Pigs
Immune response
Infection
Inflammation
Iron
Iron - metabolism
lactoferrin
Lactoferrin - biosynthesis
messenger RNA
Metabolism
Microarray Analysis
microarray technology
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Nitric oxide
Real-Time Polymerase Chain Reaction
Receptors, Transferrin - biosynthesis
reverse transcription
Solutes
Splenocytes
transferrin
Transferrin receptors
Tuberculin
Tuberculosis
Tuberculosis - prevention & control
Tumor necrosis factor- alpha
Vaccination
vaccines
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Beschreibung
Zusammenfassung:Highlights ► Splenocytes from BCG and naïve guinea pigs were used to study ferritin levels. ► Ferritin was suppressed in vaccine-derived cells after PPD stimulation. ► TNFα and NO were involved in ferritin suppression. ► Microarray revealed suppression of further iron-related genes after M. tuberculosis infection. ► The regulation of iron is an important mechanism induced by BCG-vaccination.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.03.008