Vaccination of bovines against Echinococcus granulosus (cystic echinococcosis)

Highlights ► Cattle can be successfully protected against hydatid disease using the EG95 vaccine. ► Best results were achieved with 250 μg of EG95 and 5 mg QuilA adjuvant. ► Two vaccinations resulted in 90% protection; three gave 99%.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2012-04, Vol.30 (20), p.3076-3081
Hauptverfasser:	Heath, David D, Robinson, Christine, Shakes, Trevor, Huang, Yan, Gulnur, Tursun, Shi, Baoxing, Zhang, Zhuangzhi, Anderson, Garry A, Lightowlers, Marshall W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptations Adjuvants Adjuvants, Immunologic - administration & dosage Allergy and Immunology Animals antigens Antigens, Helminth - administration & dosage Antigens, Helminth - immunology Autopsy Carnivores Cattle Cattle Diseases - prevention & control Cysts dose response Dose-Response Relationship, Immunologic echinococcosis Echinococcosis - prevention & control Echinococcus granulosus Echinococcus granulosus - immunology EG95 Eggs goats Grazing Helminth Proteins - administration & dosage Helminth Proteins - immunology humans Hydatid disease hydatids Immunization Infection monitoring necropsy oncospheres Quillaja Saponins Saponins - administration & dosage Serology sheep tapeworms Vaccination Vaccination - methods Vaccine Vaccines Vaccines - administration & dosage Vaccines - immunology zoonoses
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Beschreibung
Zusammenfassung:	Highlights ► Cattle can be successfully protected against hydatid disease using the EG95 vaccine. ► Best results were achieved with 250 μg of EG95 and 5 mg QuilA adjuvant. ► Two vaccinations resulted in 90% protection; three gave 99%.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.02.073