Relationship between CYP2E1 Polymorphism and Increase of ALT Activity during Therapy of Patients with Pulmonary Tuberculosis

Association of CYP2E1 polymorphism with ALT activity increase was studied in patients with pulmonary tuberculosis receiving therapy by intermittent and daily protocols. The greatest increment of ALT activity in the group receiving therapy by intermittent protocol was seen in the patients with CYP2E1*7632TA genotype. In patients with wild homozygotic 1 C/1 C ( 6/6 ) genotype, ALT activity signifi cantly increased, but remained within the normal range ( p = 0.048). In the group on daily regimen, activity of ALT increased signifi cantly in patients with all genotypes identifi ed. A more pronounced elevation surpassing the median of the upper threshold of ALT norm was observed in patients with 7632TA genotype ( p = 0.0051) and in patients with 7632TA or - 71GT or 1 C/1D genotypes in combinations with wild type alleles by other detected polymorphisms ( p = 0.0277). Detection of the CYP2E1 gene 7632 T > A polymorphism was found to be the most informative test for prediction of the hepatotoxic reactions during therapy for tuberculosis.