Impact of Amyloid-β Peptide (1–42) on Voltage-Gated Ion Currents in Molluscan Neurons

Different types of voltage-gated ion currents were recorded in isolated neurons of snail Helix pomatia using the two-microelectrode voltage-clamp technique. Application of amyloid-β peptide (1–42, 1–10 μM) in the bathing solution did not change delayed rectifier K + -current and leakage current, but...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2011-10, Vol.151 (6), p.671-674
Hauptverfasser:	Solntseva, E. I., Bukanova, J. V., Marchenko, E. V., Skrebitsky, V. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid beta-Peptides - pharmacology Amyloid beta-protein Animals Biomedical and Life Sciences Biomedicine Calcium Channels - drug effects Calcium Channels - metabolism Cell Biology Indexing in process Internal Medicine Laboratory Medicine Mollusca Neurons Neurons - drug effects Patch-Clamp Techniques Pathology Potassium Channels, Voltage-Gated - drug effects Potassium Channels, Voltage-Gated - metabolism
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Zusammenfassung:	Different types of voltage-gated ion currents were recorded in isolated neurons of snail Helix pomatia using the two-microelectrode voltage-clamp technique. Application of amyloid-β peptide (1–42, 1–10 μM) in the bathing solution did not change delayed rectifier K + -current and leakage current, but enhanced inactivation of Ca 2+ -current and blocked Ca 2+ -dependent К + -current.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-011-1412-y