Comparative Study of the Expression of ATF-3 and ATF-4 Genes in Vessels Involved into Atherosclerosis Process and in Psoriatic Skin

Expression of ATF-3 and ATF-4 genes was examined quantitatively by real-time PCR and changes in the expression of these genes in atherosclerotic lesions and in psoriatic skin were demonstrated. It was found that concomitant pathologies do not affect the expression of these genes. Opposite changes in...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2011-10, Vol.151 (6), p.713-716
Hauptverfasser:	Sobolev, V. V., Starodubtseva, N. L., Piruzyan, A. L., Minnibaev, M.T., Sautin, M. E., Tumanov, V. P., Bruskin, S. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 3 - genetics Activating Transcription Factor 4 - genetics Atherosclerosis Atherosclerosis - genetics Biomedical and Life Sciences Biomedicine Cell Biology Cholesterol Genes Genetic aspects Genetic transcription Genetics Humans In Vitro Techniques Indexing in process Internal Medicine Laboratory Medicine Pathology Protein binding Proteins Psoriasis Psoriasis - genetics Real-Time Polymerase Chain Reaction Skin Skin - metabolism
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Zusammenfassung:	Expression of ATF-3 and ATF-4 genes was examined quantitatively by real-time PCR and changes in the expression of these genes in atherosclerotic lesions and in psoriatic skin were demonstrated. It was found that concomitant pathologies do not affect the expression of these genes. Opposite changes in the expression of ATF-3 and ATF-4 genes in atherosclerotic and psoriatic samples were revealed and a hypothesis was put forward that this parameter could be a criterion of pathological process in both diseases.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-011-1423-8