Cupric Superoxo-Mediated Intermolecular C−H Activation Chemistry

Cupric Superoxo-Mediated Intermolecular C−H Activation Chemistry

The new cupric superoxo complex [LCuII(O2 •−)]+, which possesses particularly strong O−O and Cu−O bonding, is capable of intermolecular C−H activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with...

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Veröffentlicht in:Journal of the American Chemical Society 2011-02, Vol.133 (6), p.1702-1705
Hauptverfasser: Peterson, Ryan L., Himes, Richard A., Kotani, Hiroaki, Suenobu, Tomoyoshi, Tian, Li, Siegler, Maxime A., Solomon, Edward I., Fukuzumi, Shunichi, Karlin, Kenneth D.
Format: Artikel
Sprache:eng
Schlagworte:
Carbon - chemistry
Copper - chemistry
Hydrogen - chemistry
Kinetics
Models, Molecular
Molecular Conformation
Organometallic Compounds - chemistry
Oxidation-Reduction
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Beschreibung
Zusammenfassung:The new cupric superoxo complex [LCuII(O2 •−)]+, which possesses particularly strong O−O and Cu−O bonding, is capable of intermolecular C−H activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with a deuterium kinetic isotope effect (KIE) of 12.1, similar to that observed for certain copper monooxygenases.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja110466q