Expression of infectious pancreatic necrosis virus (IPNV) VP2–VP3 fusion protein in Lactobacillus casei and immunogenicity in rainbow trouts

Highlights ► We constructed recombinant lactobacillus expressing IPNV VP2–VP3 fusion protein. ► We analyzed its immunogenicity in rainbow trouts by orogastrical administration. ► We performed the comparison of immunogenicity of recombinant surface-displayed and secretory strains.

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Veröffentlicht in:	Vaccine 2012-02, Vol.30 (10), p.1823-1829
Hauptverfasser:	Li-Li, Zhao, Min, Liu, Jun-Wei, Ge, Xin-Yuan, Qiao, Yi-Jing, Li, Di-Qiu, Liu
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Allergy and Immunology Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Birnaviridae Infections - prevention & control Birnaviridae Infections - veterinary blood serum Escherichia coli Fish Diseases - prevention & control Fish Diseases - virology gene fusion genetic vectors immune response Immunity, Mucosal immunoglobulin M Immunoglobulin M - blood Infectious pancreatic necrosis virus Infectious pancreatic necrosis virus - immunology Lactobacillus Lactobacillus casei Lactobacillus casei - immunology mortality Mucosal vaccine neutralization Neutralization Tests Oncorhynchus mykiss Oncorhynchus mykiss - immunology Oncorhynchus mykiss - virology Rainbow trout Recombinant Fusion Proteins - immunology reverse transcriptase polymerase chain reaction Salmonidae statistical analysis trout vaccines Viral Load Viral Structural Proteins - immunology Viral Vaccines - administration & dosage Viral Vaccines - immunology viruses VP2–VP3 fusion
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Beschreibung
Zusammenfassung:	Highlights ► We constructed recombinant lactobacillus expressing IPNV VP2–VP3 fusion protein. ► We analyzed its immunogenicity in rainbow trouts by orogastrical administration. ► We performed the comparison of immunogenicity of recombinant surface-displayed and secretory strains.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.12.132