A new functional role of HIV-1 integrase during uncoating of the viral core

An early and critical event of the human immunodeficiency virus type 1 (HIV-1) life cycle is uncoating of the viral core. Uncoating involves the disassembly of HIV-1 capsid (CA). The underlying mechanisms governing uncoating are poorly defined, and the role of viral and host factors in uncoating is...

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Veröffentlicht in:	Immunologic research 2010-12, Vol.48 (1-3), p.14-26
Hauptverfasser:	Briones, Marisa S., Chow, Samson A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Biomedical and Life Sciences Biomedicine Capsid Proteins - metabolism Capsids Carrier Proteins - metabolism Cellular biology Cyclophilin A - metabolism HIV HIV Infections - immunology HIV Infections - virology HIV Integrase - metabolism HIV-1 - pathogenicity HIV-1 - physiology Host-Pathogen Interactions Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immunology Integrase Internal Medicine Life cycle Life cycles Medicine/Public Health Peptidylprolyl isomerase Replication Reviews Uncoating Viral Core Proteins - metabolism Virology Virus Integration Virus Replication
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Beschreibung
Zusammenfassung:	An early and critical event of the human immunodeficiency virus type 1 (HIV-1) life cycle is uncoating of the viral core. Uncoating involves the disassembly of HIV-1 capsid (CA). The underlying mechanisms governing uncoating are poorly defined, and the role of viral and host factors in uncoating is not well understood. Cyclophilin A and TRIM5α are two cellular factors that interact with CA in exerting their effects on HIV-1 replication. Here, we review the current understanding of uncoating and the new functional role of HIV-1 IN during uncoating.
ISSN:	0257-277X 1559-0755
DOI:	10.1007/s12026-010-8164-z