Light sheet microscopy of living or cleared specimens
Highlights ► We review the history of light sheet microscopy and discuss recent technical breakthroughs. ► We discuss tissue clearing methods and their combination with light sheet imaging. ► Light sheet microscopy provides exceptionally high imaging speeds and low rates of photo-bleaching. ► Recent...
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| Veröffentlicht in: | Current opinion in neurobiology 2012-02, Vol.22 (1), p.138-143 |
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| container_end_page | 143 |
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| container_issue | 1 |
| container_start_page | 138 |
| container_title | Current opinion in neurobiology |
| container_volume | 22 |
| creator | Keller, Philipp J Dodt, Hans-Ulrich |
| description | Highlights ► We review the history of light sheet microscopy and discuss recent technical breakthroughs. ► We discuss tissue clearing methods and their combination with light sheet imaging. ► Light sheet microscopy provides exceptionally high imaging speeds and low rates of photo-bleaching. ► Recent technical advances include improvements in spatial resolution and penetration depth. ► Light sheet microscopy is a powerful emerging tool for the observation of live and fixed specimens. |
| doi_str_mv | 10.1016/j.conb.2011.08.003 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0959-4388 |
| ispartof | Current opinion in neurobiology, 2012-02, Vol.22 (1), p.138-143 |
| issn | 0959-4388 1873-6882 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | History, 20th Century Microscopy - history Microscopy - instrumentation Microscopy - methods Neurology Psychiatry |
| title | Light sheet microscopy of living or cleared specimens |
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