Novel Hepatitis C virus replicon inhibitors: Synthesis and structure–activity relationships of fused pyrimidine derivatives

The synthesis of several pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine analogs is described with one such analog possessing subnanomolar potency in both genotype 1a and 1b cell culture HCV replicon assays.

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-03, Vol.22 (6), p.2212-2215
Hauptverfasser:	Chris Krueger, A., Madigan, Darold L., Beno, David W., Betebenner, David A., Carrick, Robert, Green, Brian E., He, Wenping, Liu, Dachun, Maring, Clarence J., McDaniel, Keith F., Mo, Hongmei, Molla, Akhteruzzaman, Motter, Christopher E., Pilot-Matias, Tami J., Tufano, Michael D., Kempf, Dale J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Biological and medical sciences Cell culture Cell Line, Tumor Genotype Genotypes Hepacivirus - drug effects Hepacivirus - physiology Hepatitis C Hepatitis C virus Humans Medical sciences Pharmacology. Drug treatments Pyrido[2,3-d]pyrimidines pyrimidines Pyrimidines - chemical synthesis Pyrimidines - pharmacology Pyrimido[4,5-d]pyrimidines replicon Replicon - drug effects Replicon inhibitors RNA, Viral - antagonists & inhibitors RNA, Viral - biosynthesis Structure-Activity Relationship Structure-activity relationships Virus Replication - drug effects
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Zusammenfassung:	The synthesis of several pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine analogs is described with one such analog possessing subnanomolar potency in both genotype 1a and 1b cell culture HCV replicon assays.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2012.01.096