Clinical disease in sheep caused by bluetongue virus serotype 8, and prevention by an inactivated vaccine

Highlights ► BTV-8 grown in mammalian or Culicoides cell-cultures used for challenge infection. ► Both BTV-8 virus preparations induced severe clinical signs in adult unvaccinated sheep. ► Vaccination reduced clinical signs and viraemia equally well after infection with both viruses.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2012-03, Vol.30 (12), p.2228-2235
Hauptverfasser:	Moulin, Véronique, Noordegraaf, Cor Vonk, Makoschey, Birgit, van der Sluijs, Mirjam, Veronesi, Eva, Darpel, Karin, Mertens, Peter P.C, de Smit, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology animal health Animals Antibodies Antibodies, Neutralizing - blood Antibodies, Viral - blood blood serum Bluetongue Bluetongue - immunology Bluetongue - pathology Bluetongue - prevention & control Bluetongue virus Bluetongue virus - immunology Bluetongue virus - pathogenicity Challenge model Clinical signs Culicoides Disease Fever Immunization Infections insects Mortality neutralization neutralizing antibodies Pest outbreaks Serotypes Severity of Illness Index Sheep Studies Texel Vaccination Vaccines Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - immunology Viral Load Viral Vaccines - administration & dosage Viral Vaccines - immunology Viremia Viremia - pathology Viremia - prevention & control virus transmission viruses
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Beschreibung
Zusammenfassung:	Highlights ► BTV-8 grown in mammalian or Culicoides cell-cultures used for challenge infection. ► Both BTV-8 virus preparations induced severe clinical signs in adult unvaccinated sheep. ► Vaccination reduced clinical signs and viraemia equally well after infection with both viruses.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.11.100