A case report of a patient with rheumatoid arthritis complicated with Mycobacterium avium during tocilizumab treatment

A female patient with rheumatoid arthritis (RA) suffered from Mycobacterium avium ( M. avium ) infection during tocilizumab treatment. Tocilizumab was discontinued and she was treated with a recommended chemotherapy, resulting in improvement of M. avium . Tocilizumab retreatment did not aggravate M....

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Veröffentlicht in:	Modern rheumatology 2011-12, Vol.21 (6), p.655-659
Hauptverfasser:	Nakahara, Hideko, Kamide, Yosuke, Hamano, Yoshimasa, Hosokawa, Takashi, Nishide, Masayuki, Lin, Yu, Kawamoto, Keisuke, Fusama, Mie, Higa, Shinji, Kuroiwa, Takashi, Igarashi, Tsuyoshi, Kuritani, Taro, Maeda, Keiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal, Humanized - therapeutic use Antirheumatic Agents - therapeutic use Antitubercular Agents - therapeutic use Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - drug therapy Bacterial infections Case management Case Report Case reports Chemotherapy Clarithromycin - therapeutic use Drug therapy Ethambutol - therapeutic use Female Humans Infection Medicine Medicine & Public Health Middle Aged Mycobacterium avium Mycobacterium avium-intracellulare Infection - complications Mycobacterium avium-intracellulare Infection - drug therapy Orthopedics Rheumatoid arthritis Rheumatology Rifampin - therapeutic use Treatment Outcome
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Zusammenfassung:	A female patient with rheumatoid arthritis (RA) suffered from Mycobacterium avium ( M. avium ) infection during tocilizumab treatment. Tocilizumab was discontinued and she was treated with a recommended chemotherapy, resulting in improvement of M. avium . Tocilizumab retreatment did not aggravate M. avium infection, and radiographic abnormalities improved over 1 year after cessation of the recommended therapy. Tocilizumab may be one candidate for intractable RA patients with M. avium if any biologic is required.
ISSN:	1439-7595 1439-7609
DOI:	10.1007/s10165-011-0448-1