Streptococcus pneumoniae pep27 mutant as a live vaccine for serotype-independent protection in mice

Highlights ► Pep27 is known to mediate lysis. ► Effect of the pep27 mutation on virulence was examined. ► The pep27 mutant showed rapid clearance and could not invade into the tissue. ► The pep27 mutant without adjuvant provides protective intranasal immunity.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2012-03, Vol.30 (11), p.2008-2019
Hauptverfasser:	Kim, Eun-Hye, Choi, Sang-Yoon, Kwon, Min-Kyoung, Tran, Thao Dang-Hien, Park, Sang-Sang, Lee, Kwang-Jun, Bae, Song-Mee, Briles, David E, Rhee, Dong-Kwon
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Allergy and Immunology Animals antibiotic resistance Antibodies, Bacterial - blood bacteremia blood brain Cross-protection Immunity immunization immunoglobulin G Immunoglobulin G - blood intravenous injection Live vaccine live vaccines Male Mice morbidity mortality mutants Mutation pep27 mutant Pneumococcal Infections - prevention & control Pneumococcal Vaccines - immunology serotypes Streptococcus pneumoniae Streptococcus pneumoniae - genetics Streptococcus pneumoniae - pathogenicity Streptococcus pneumoniae - ultrastructure Vaccines, Attenuated - immunology Virulence
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Beschreibung
Zusammenfassung:	Highlights ► Pep27 is known to mediate lysis. ► Effect of the pep27 mutation on virulence was examined. ► The pep27 mutant showed rapid clearance and could not invade into the tissue. ► The pep27 mutant without adjuvant provides protective intranasal immunity.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.11.073