Genetic Control of Nickel Sulfate Delayed-Type Hypersensitivity

Genetic Control of Nickel Sulfate Delayed-Type Hypersensitivity

Genetic control of delayed-type hypersensitivity (DTH) to nickel sulfate antigen was studied using various strains on inbred mice. Mice with class II Ad,k,s haplotypes showed a high magnitude of response, whereas those with class II Ab,f were low responders. These results indicate that nickel sulfat...

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Veröffentlicht in:Journal of investigative dermatology 1990-05, Vol.94 (5), p.673-676
Hauptverfasser: Ishii, Norihisa, Ishii, Harumi, Ono, Hideki, Horiuchi, Yoshihito, Nakajima, Hiroshi, Aoki, Ichiro
Format: Artikel
Sprache:eng
Schlagworte:
Allergic diseases
Animals
Antibodies, Monoclonal - therapeutic use
Biological and medical sciences
Dermatitis, Atopic - chemically induced
Dermatology
Drug Hypersensitivity - genetics
Female
Genetic control
Haplotypes
Histocompatibility antigen H-2
Hypersensitivity (delayed)
Hypersensitivity, Delayed - genetics
Immunopathology
Inbreeding
Lymph Nodes - immunology
Medical sciences
Mice
Mice, Inbred Strains
Nickel
Nickel - adverse effects
Nickel - blood
Nickel - immunology
Skin allergic diseases. Stinging insect allergies
Sulfate
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Zusammenfassung:Genetic control of delayed-type hypersensitivity (DTH) to nickel sulfate antigen was studied using various strains on inbred mice. Mice with class II Ad,k,s haplotypes showed a high magnitude of response, whereas those with class II Ab,f were low responders. These results indicate that nickel sulfate DTH may be influenced by the I-A region of H-2. Transfer experiments revealed that these responses might be mediated by L3T4+ Lyt-2− T cells.
ISSN:0022-202X
1523-1747
DOI:10.1111/1523-1747.ep12876249