Fifty-year old samples of progesterone demonstrate the complex role of synthetic impurities in stabilizing a metastable polymorph

We describe a unique experiment whereby analysis of fifty-year old samples of progesterone shows that a metastable, 'disappearing' polymorph contains several impurities that are not found in the stable form.

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Veröffentlicht in:CrystEngComm 2011-01, Vol.13 (6), p.1775-1777
Hauptverfasser: Lancaster, Robert W, Harris, Lisa D, Pearson, David
Format: Artikel
Sprache:eng
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Zusammenfassung:We describe a unique experiment whereby analysis of fifty-year old samples of progesterone shows that a metastable, 'disappearing' polymorph contains several impurities that are not found in the stable form.
ISSN:1466-8033
1466-8033
DOI:10.1039/C0CE00858C