Investigating the structural biofunctionality of antibodies conjugated to magnetic nanoparticles

We present the synthesis of trastuzumab-functionalized pegylated iron oxide nanoparticles and provide an FTIR-based approach to gain a direct evidence of the actual conservation of the native structure of conjugated antibody. Their target-selectivity to specific cancer cell receptors has been also a...

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Veröffentlicht in:	Nanoscale 2011-02, Vol.3 (2), p.387-390
Hauptverfasser:	Occhipinti, Emanuela, Verderio, Paolo, Natalello, Antonino, Galbiati, Elisabetta, Colombo, Miriam, Mazzucchelli, Serena, Salvadè, Agnese, Tortora, Paolo, Doglia, Silvia Maria, Prosperi, Davide
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies - chemistry Antibodies, Monoclonal - chemistry Antibodies, Monoclonal, Humanized Aspartic Acid - analogs & derivatives Aspartic Acid - chemistry Cell Line, Tumor Ferric Compounds - chemistry Fluorescein-5-isothiocyanate - chemistry Gain Humans Immunoconjugates - chemistry Immunoprecipitation Iron oxides Magnetics Metal Nanoparticles - chemistry Microscopy, Confocal Morpholines - chemistry Nanocomposites Nanomaterials Nanoparticles Nanostructure Receptors Spectroscopy, Fourier Transform Infrared Trastuzumab
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Beschreibung
Zusammenfassung:	We present the synthesis of trastuzumab-functionalized pegylated iron oxide nanoparticles and provide an FTIR-based approach to gain a direct evidence of the actual conservation of the native structure of conjugated antibody. Their target-selectivity to specific cancer cell receptors has been also assessed.
ISSN:	2040-3364 2040-3372
DOI:	10.1039/c0nr00436g